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Glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper

INTRODUCTION: Due to increased human activity, the amount of copper in air, soil and water has increased. Copper, at minimum concentrations, is essential for the normal functioning of the organism (cellular respiration, hemoglobin formation, growth and reproduction). At higher concentrations, copper...

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Autores principales: Mirkovic, J. Jovanovic, Jurinjak, Z., Kocic, G., Medojevic, N., Alexopoulos, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479844/
http://dx.doi.org/10.1192/j.eurpsy.2021.1906
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author Mirkovic, J. Jovanovic
Jurinjak, Z.
Kocic, G.
Medojevic, N.
Alexopoulos, C.
author_facet Mirkovic, J. Jovanovic
Jurinjak, Z.
Kocic, G.
Medojevic, N.
Alexopoulos, C.
author_sort Mirkovic, J. Jovanovic
collection PubMed
description INTRODUCTION: Due to increased human activity, the amount of copper in air, soil and water has increased. Copper, at minimum concentrations, is essential for the normal functioning of the organism (cellular respiration, hemoglobin formation, growth and reproduction). At higher concentrations, copper is deposited in the liver, brain tissue, and bone marrow. OBJECTIVES: To investigate the protective role of the supplement, glutathione (GSH), the S-donor ligand, in conditions of chronic copper intoxication via the parameters of oxidative stress, ie. Alkaline and acidic DNase values in brain tissue in albino rats of Wistar strain. METHODS: The model system for testing the effects of copper exposure and the protective effect of GSH was a study on female albino rats of Wistar strain, stored in the vivarium of the Scientific Research Center for Biomedicine, Faculty of Medicine, Niš, Serbia. Endonucleases, alkaline and acidic DNase activities were determined spectrophotometrically from homogenates of brain tissue. RESULTS: Copper is believed to be a likely cause of oxidative damage to the DNA molecule, as manifested by increased alkaline and acidic DNase activity. The results of this study show that GSH is a potent chelator that binds copper and enables its elimination from the body. CONCLUSIONS: In this experiment, the beneficial role of GSH supplements, which has an antioxidant character, in the prevention and reduction of the adverse effects of chronic copper intoxication was demonstrated. In this way, GSH acts as a powerful protector and antioxidant. DISCLOSURE: No significant relationships.
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spelling pubmed-94798442022-09-29 Glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper Mirkovic, J. Jovanovic Jurinjak, Z. Kocic, G. Medojevic, N. Alexopoulos, C. Eur Psychiatry Abstract INTRODUCTION: Due to increased human activity, the amount of copper in air, soil and water has increased. Copper, at minimum concentrations, is essential for the normal functioning of the organism (cellular respiration, hemoglobin formation, growth and reproduction). At higher concentrations, copper is deposited in the liver, brain tissue, and bone marrow. OBJECTIVES: To investigate the protective role of the supplement, glutathione (GSH), the S-donor ligand, in conditions of chronic copper intoxication via the parameters of oxidative stress, ie. Alkaline and acidic DNase values in brain tissue in albino rats of Wistar strain. METHODS: The model system for testing the effects of copper exposure and the protective effect of GSH was a study on female albino rats of Wistar strain, stored in the vivarium of the Scientific Research Center for Biomedicine, Faculty of Medicine, Niš, Serbia. Endonucleases, alkaline and acidic DNase activities were determined spectrophotometrically from homogenates of brain tissue. RESULTS: Copper is believed to be a likely cause of oxidative damage to the DNA molecule, as manifested by increased alkaline and acidic DNase activity. The results of this study show that GSH is a potent chelator that binds copper and enables its elimination from the body. CONCLUSIONS: In this experiment, the beneficial role of GSH supplements, which has an antioxidant character, in the prevention and reduction of the adverse effects of chronic copper intoxication was demonstrated. In this way, GSH acts as a powerful protector and antioxidant. DISCLOSURE: No significant relationships. Cambridge University Press 2021-08-13 /pmc/articles/PMC9479844/ http://dx.doi.org/10.1192/j.eurpsy.2021.1906 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Mirkovic, J. Jovanovic
Jurinjak, Z.
Kocic, G.
Medojevic, N.
Alexopoulos, C.
Glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper
title Glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper
title_full Glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper
title_fullStr Glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper
title_full_unstemmed Glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper
title_short Glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper
title_sort glutathione as a powerful antioxidant in oxidative stress in the brain tissue of rats caused by the pathophysiological action of copper
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479844/
http://dx.doi.org/10.1192/j.eurpsy.2021.1906
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