Cargando…

Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam

INTRODUCTION: Genome-wide association studies (GWAS) have successfully revealed genetic risk variants for schizophrenia (SCZ). However, the vast majority of GWAS largely comprise European samples. As a result, the derived polygenic risk scores (PRS) show decreased predictive power when applied to no...

Descripción completa

Detalles Bibliográficos
Autores principales: Braun, A., Nguyen, T.V., Ripke, S., Nguyen, P.V., Kraft, J., Nguyen, H.T., Le, T.C., Panagiotaropoulou, G., Hahne, I.M., Böge, K., Hahn, E., Ta, T.M.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479969/
http://dx.doi.org/10.1192/j.eurpsy.2021.2122
_version_ 1784790923542003712
author Braun, A.
Nguyen, T.V.
Ripke, S.
Nguyen, P.V.
Kraft, J.
Nguyen, H.T.
Le, T.C.
Panagiotaropoulou, G.
Hahne, I.M.
Böge, K.
Hahn, E.
Ta, T.M.T.
author_facet Braun, A.
Nguyen, T.V.
Ripke, S.
Nguyen, P.V.
Kraft, J.
Nguyen, H.T.
Le, T.C.
Panagiotaropoulou, G.
Hahne, I.M.
Böge, K.
Hahn, E.
Ta, T.M.T.
author_sort Braun, A.
collection PubMed
description INTRODUCTION: Genome-wide association studies (GWAS) have successfully revealed genetic risk variants for schizophrenia (SCZ). However, the vast majority of GWAS largely comprise European samples. As a result, the derived polygenic risk scores (PRS) show decreased predictive power when applied to non-European populations. OBJECTIVES: A long-term scientific cooperation between the Charité Universitätsmedizin Berlin and the Hanoi Medical University aims to address this limitation by recruiting a large genetic cohort of comprehensively phenotyped schizophrenia patients and controls in Vietnam. METHODS: A pilot study was conducted at the Department of Psychiatry of the Medical University Hanoi in 2017. Data collection encompassed i) genome-wide SNP genotyping of 200 schizophrenia patients and 200 control subjects ii) structured interviews to assess symptom severity (PANSS), iii) clinical parameters (e.g. duration of illness, medication) and demography. RESULTS: SCZ-PRS of the pilot sample (N=400) were generated using different training data sets: i) European, ii) East-Asian and iii) mixed GWAS summary statistics from the Psychiatric Genomics Consortium’s latest discovery sample. Most variance explained was observed using a mixed discovery sample (R(2)liability=0.053, p=3.11*10(-8), Pd <0.5), followed by PRS based on the East-Asian summary statistics (R(2)liability=0.0503, p=6.78*10(-8), Pd <1) and the European sample (R(2)liability=0.0363, p = 4.26*10(-6), Pd <0.01). CONCLUSIONS: With this pilot project we established an efficient recruitment, genotyping and data analysis pipeline. Our results corroborate previous findings indicating that transferability of PRS across populations depends on the ancestral composition of the initial discovery dataset. We therefore aim to expand data collection efforts in the future in order to improve risk prediction across diverse populations. DISCLOSURE: No significant relationships.
format Online
Article
Text
id pubmed-9479969
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-94799692022-09-29 Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam Braun, A. Nguyen, T.V. Ripke, S. Nguyen, P.V. Kraft, J. Nguyen, H.T. Le, T.C. Panagiotaropoulou, G. Hahne, I.M. Böge, K. Hahn, E. Ta, T.M.T. Eur Psychiatry Abstract INTRODUCTION: Genome-wide association studies (GWAS) have successfully revealed genetic risk variants for schizophrenia (SCZ). However, the vast majority of GWAS largely comprise European samples. As a result, the derived polygenic risk scores (PRS) show decreased predictive power when applied to non-European populations. OBJECTIVES: A long-term scientific cooperation between the Charité Universitätsmedizin Berlin and the Hanoi Medical University aims to address this limitation by recruiting a large genetic cohort of comprehensively phenotyped schizophrenia patients and controls in Vietnam. METHODS: A pilot study was conducted at the Department of Psychiatry of the Medical University Hanoi in 2017. Data collection encompassed i) genome-wide SNP genotyping of 200 schizophrenia patients and 200 control subjects ii) structured interviews to assess symptom severity (PANSS), iii) clinical parameters (e.g. duration of illness, medication) and demography. RESULTS: SCZ-PRS of the pilot sample (N=400) were generated using different training data sets: i) European, ii) East-Asian and iii) mixed GWAS summary statistics from the Psychiatric Genomics Consortium’s latest discovery sample. Most variance explained was observed using a mixed discovery sample (R(2)liability=0.053, p=3.11*10(-8), Pd <0.5), followed by PRS based on the East-Asian summary statistics (R(2)liability=0.0503, p=6.78*10(-8), Pd <1) and the European sample (R(2)liability=0.0363, p = 4.26*10(-6), Pd <0.01). CONCLUSIONS: With this pilot project we established an efficient recruitment, genotyping and data analysis pipeline. Our results corroborate previous findings indicating that transferability of PRS across populations depends on the ancestral composition of the initial discovery dataset. We therefore aim to expand data collection efforts in the future in order to improve risk prediction across diverse populations. DISCLOSURE: No significant relationships. Cambridge University Press 2021-08-13 /pmc/articles/PMC9479969/ http://dx.doi.org/10.1192/j.eurpsy.2021.2122 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Braun, A.
Nguyen, T.V.
Ripke, S.
Nguyen, P.V.
Kraft, J.
Nguyen, H.T.
Le, T.C.
Panagiotaropoulou, G.
Hahne, I.M.
Böge, K.
Hahn, E.
Ta, T.M.T.
Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam
title Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam
title_full Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam
title_fullStr Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam
title_full_unstemmed Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam
title_short Introducing a psychiatric genetic cohort of schizophrenia patients and controls from Vietnam
title_sort introducing a psychiatric genetic cohort of schizophrenia patients and controls from vietnam
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9479969/
http://dx.doi.org/10.1192/j.eurpsy.2021.2122
work_keys_str_mv AT brauna introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT nguyentv introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT ripkes introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT nguyenpv introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT kraftj introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT nguyenht introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT letc introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT panagiotaropouloug introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT hahneim introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT bogek introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT hahne introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam
AT tatmt introducingapsychiatricgeneticcohortofschizophreniapatientsandcontrolsfromvietnam