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Did the effect of placebo increase in rcts of panic disorder across the years?

INTRODUCTION: The curious effect of an increase of the placebo effect across year of publication has been shown for depression, schizophrenia, obsessive-compulsive disorder, as well as for some medical conditions like hypertension and pain. OBJECTIVES: We aimed to observe how randomised clinical tri...

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Autores principales: Segni, F. Di, Zoppi, T., Forcina, F., Anibaldi, G., Bargagna, P., Telesforo, C.L., Montebovi, F., Callovini, G., Giuseppin, G., Janiri, D., Molinaro, M., Sani, G., Kotzalidis, G.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480214/
http://dx.doi.org/10.1192/j.eurpsy.2021.1627
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author Segni, F. Di
Zoppi, T.
Forcina, F.
Anibaldi, G.
Bargagna, P.
Telesforo, C.L.
Montebovi, F.
Callovini, G.
Giuseppin, G.
Janiri, D.
Molinaro, M.
Sani, G.
Kotzalidis, G.D.
author_facet Segni, F. Di
Zoppi, T.
Forcina, F.
Anibaldi, G.
Bargagna, P.
Telesforo, C.L.
Montebovi, F.
Callovini, G.
Giuseppin, G.
Janiri, D.
Molinaro, M.
Sani, G.
Kotzalidis, G.D.
author_sort Segni, F. Di
collection PubMed
description INTRODUCTION: The curious effect of an increase of the placebo effect across year of publication has been shown for depression, schizophrenia, obsessive-compulsive disorder, as well as for some medical conditions like hypertension and pain. OBJECTIVES: We aimed to observe how randomised clinical trials with a placebo control behave at this respect in panic disorder trials. METHODS: We searched the PubMed database using the strategy: (panic disorder OR panic attack disorder) AND placebo, which on 3 November 2020 produced 779 records. Inclusion criteria were the above stated, excluded were all studies focusing on the same patients as others and those not providing intelligible data. In our selection we used the PRISMA statement and reached agreement with Delphi rounds. RESULTS: We identified through other sources further 3 studies. The finally eligible studies were 82, excluded were 700 studies, mainly consisting of reviews (176), challenge studies (173), not dealing with panic disorder (67), studies with unsuitable designs to detect placebo effect (53), studies using same populations as others (36), those with misfocused outcomes (57), those lumping diagnoses and not allowing to separate data for panic disorder (22), and those not using placebo at all (21). Mean response to placebo in included panic disorder studies was 36.01±19.812, ranging from 0 to 76.19%; the correlation with year of publication was positive and significant (Pearson’s r= 0.246; p=0.026). CONCLUSIONS: The effect of placebo in randomised control trials has increased across the years, but this field of research appears to be idle in recent years. DISCLOSURE: No significant relationships.
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spelling pubmed-94802142022-09-29 Did the effect of placebo increase in rcts of panic disorder across the years? Segni, F. Di Zoppi, T. Forcina, F. Anibaldi, G. Bargagna, P. Telesforo, C.L. Montebovi, F. Callovini, G. Giuseppin, G. Janiri, D. Molinaro, M. Sani, G. Kotzalidis, G.D. Eur Psychiatry Abstract INTRODUCTION: The curious effect of an increase of the placebo effect across year of publication has been shown for depression, schizophrenia, obsessive-compulsive disorder, as well as for some medical conditions like hypertension and pain. OBJECTIVES: We aimed to observe how randomised clinical trials with a placebo control behave at this respect in panic disorder trials. METHODS: We searched the PubMed database using the strategy: (panic disorder OR panic attack disorder) AND placebo, which on 3 November 2020 produced 779 records. Inclusion criteria were the above stated, excluded were all studies focusing on the same patients as others and those not providing intelligible data. In our selection we used the PRISMA statement and reached agreement with Delphi rounds. RESULTS: We identified through other sources further 3 studies. The finally eligible studies were 82, excluded were 700 studies, mainly consisting of reviews (176), challenge studies (173), not dealing with panic disorder (67), studies with unsuitable designs to detect placebo effect (53), studies using same populations as others (36), those with misfocused outcomes (57), those lumping diagnoses and not allowing to separate data for panic disorder (22), and those not using placebo at all (21). Mean response to placebo in included panic disorder studies was 36.01±19.812, ranging from 0 to 76.19%; the correlation with year of publication was positive and significant (Pearson’s r= 0.246; p=0.026). CONCLUSIONS: The effect of placebo in randomised control trials has increased across the years, but this field of research appears to be idle in recent years. DISCLOSURE: No significant relationships. Cambridge University Press 2021-08-13 /pmc/articles/PMC9480214/ http://dx.doi.org/10.1192/j.eurpsy.2021.1627 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Segni, F. Di
Zoppi, T.
Forcina, F.
Anibaldi, G.
Bargagna, P.
Telesforo, C.L.
Montebovi, F.
Callovini, G.
Giuseppin, G.
Janiri, D.
Molinaro, M.
Sani, G.
Kotzalidis, G.D.
Did the effect of placebo increase in rcts of panic disorder across the years?
title Did the effect of placebo increase in rcts of panic disorder across the years?
title_full Did the effect of placebo increase in rcts of panic disorder across the years?
title_fullStr Did the effect of placebo increase in rcts of panic disorder across the years?
title_full_unstemmed Did the effect of placebo increase in rcts of panic disorder across the years?
title_short Did the effect of placebo increase in rcts of panic disorder across the years?
title_sort did the effect of placebo increase in rcts of panic disorder across the years?
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480214/
http://dx.doi.org/10.1192/j.eurpsy.2021.1627
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