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A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression

OBJECTIVE: Two subregions of the dorsolateral prefrontal cortex have been identified as effective repetitive transcranial magnetic stimulation (rTMS) targets for the “anxiosomatic” and “dysphoric” symptoms, respectively. We aimed to develop a convenient approach to locate these targets on the scalp....

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Autores principales: Du, Rongrong, Zhou, Qian, Hu, Tianzheng, Sun, Jinmei, Hua, Qiang, Wang, Yingru, Zhang, Yuanyuan, He, Kongliang, Tian, Yanghua, Ji, Gong-Jun, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480500/
https://www.ncbi.nlm.nih.gov/pubmed/36118495
http://dx.doi.org/10.3389/fpsyg.2022.919944
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author Du, Rongrong
Zhou, Qian
Hu, Tianzheng
Sun, Jinmei
Hua, Qiang
Wang, Yingru
Zhang, Yuanyuan
He, Kongliang
Tian, Yanghua
Ji, Gong-Jun
Wang, Kai
author_facet Du, Rongrong
Zhou, Qian
Hu, Tianzheng
Sun, Jinmei
Hua, Qiang
Wang, Yingru
Zhang, Yuanyuan
He, Kongliang
Tian, Yanghua
Ji, Gong-Jun
Wang, Kai
author_sort Du, Rongrong
collection PubMed
description OBJECTIVE: Two subregions of the dorsolateral prefrontal cortex have been identified as effective repetitive transcranial magnetic stimulation (rTMS) targets for the “anxiosomatic” and “dysphoric” symptoms, respectively. We aimed to develop a convenient approach to locate these targets on the scalp. MATERIALS AND METHODS: In a discovery experiment, the two personalized targets were precisely identified on 24 subjects using a neuronavigation system. Then, a localized approach was developed based on individual scalp landmarks. This “landmark-based approach” was replicated and validated in an independent cohort (N = 25). Reliability of the approach was tested by calculating the correlation of both the inter-rater and intra-rater results. Validity was tested by comparing the mean distance between the personalized and landmark-based targets to the TMS spatial resolution (i.e., 5 mm). We further conducted a total of 24 sham rTMS sessions to estimate the misplacement between the coil center and target during a 10-min stimulation without neuronavigation. RESULTS: The parameters of the “landmark-based approach” in the discovery experiment were replicated well in an independent cohort. Using discovery parameters, we successfully identified the symptom-specific targets in the independent cohort. Specifically, the mean distance between the personalized and landmark-based targets on the cortex was not significantly larger than 5 mm. However, the personalized and landmark-based targets distance exceeded 5 mm in more than 50% of subjects. During the 10-min sham rTMS session, the average coil misplacement was significantly larger than 5 mm. CONCLUSION: The “landmark-based approach” can conveniently and reliably locate the two symptom-specific targets at group level. However, the accuracy was highly varied at individual level and further improvement is needed.
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spelling pubmed-94805002022-09-17 A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression Du, Rongrong Zhou, Qian Hu, Tianzheng Sun, Jinmei Hua, Qiang Wang, Yingru Zhang, Yuanyuan He, Kongliang Tian, Yanghua Ji, Gong-Jun Wang, Kai Front Psychol Psychology OBJECTIVE: Two subregions of the dorsolateral prefrontal cortex have been identified as effective repetitive transcranial magnetic stimulation (rTMS) targets for the “anxiosomatic” and “dysphoric” symptoms, respectively. We aimed to develop a convenient approach to locate these targets on the scalp. MATERIALS AND METHODS: In a discovery experiment, the two personalized targets were precisely identified on 24 subjects using a neuronavigation system. Then, a localized approach was developed based on individual scalp landmarks. This “landmark-based approach” was replicated and validated in an independent cohort (N = 25). Reliability of the approach was tested by calculating the correlation of both the inter-rater and intra-rater results. Validity was tested by comparing the mean distance between the personalized and landmark-based targets to the TMS spatial resolution (i.e., 5 mm). We further conducted a total of 24 sham rTMS sessions to estimate the misplacement between the coil center and target during a 10-min stimulation without neuronavigation. RESULTS: The parameters of the “landmark-based approach” in the discovery experiment were replicated well in an independent cohort. Using discovery parameters, we successfully identified the symptom-specific targets in the independent cohort. Specifically, the mean distance between the personalized and landmark-based targets on the cortex was not significantly larger than 5 mm. However, the personalized and landmark-based targets distance exceeded 5 mm in more than 50% of subjects. During the 10-min sham rTMS session, the average coil misplacement was significantly larger than 5 mm. CONCLUSION: The “landmark-based approach” can conveniently and reliably locate the two symptom-specific targets at group level. However, the accuracy was highly varied at individual level and further improvement is needed. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9480500/ /pubmed/36118495 http://dx.doi.org/10.3389/fpsyg.2022.919944 Text en Copyright © 2022 Du, Zhou, Hu, Sun, Hua, Wang, Zhang, He, Tian, Ji and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Du, Rongrong
Zhou, Qian
Hu, Tianzheng
Sun, Jinmei
Hua, Qiang
Wang, Yingru
Zhang, Yuanyuan
He, Kongliang
Tian, Yanghua
Ji, Gong-Jun
Wang, Kai
A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression
title A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression
title_full A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression
title_fullStr A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression
title_full_unstemmed A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression
title_short A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression
title_sort landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480500/
https://www.ncbi.nlm.nih.gov/pubmed/36118495
http://dx.doi.org/10.3389/fpsyg.2022.919944
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