New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?

There are a wide variety of disfiguring dermatological conditions whose pathologic substrate is represented by the unwanted deposition of collagen from dermal fibroblasts. Pirfenidone has demonstrated efficiency in the treatment of disordered collagen production when applied topically. Due to a simi...

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Autores principales: Cristodor, Patricia Liana, Nechifor, Alexandru, Fotea, Silvia, Nadasdy, Thomas, Bahloul, Yousef, Nicolescu, Alin Codrut, Tatu, Alin Laurentiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480593/
https://www.ncbi.nlm.nih.gov/pubmed/36118185
http://dx.doi.org/10.2147/IJGM.S377073
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author Cristodor, Patricia Liana
Nechifor, Alexandru
Fotea, Silvia
Nadasdy, Thomas
Bahloul, Yousef
Nicolescu, Alin Codrut
Tatu, Alin Laurentiu
author_facet Cristodor, Patricia Liana
Nechifor, Alexandru
Fotea, Silvia
Nadasdy, Thomas
Bahloul, Yousef
Nicolescu, Alin Codrut
Tatu, Alin Laurentiu
author_sort Cristodor, Patricia Liana
collection PubMed
description There are a wide variety of disfiguring dermatological conditions whose pathologic substrate is represented by the unwanted deposition of collagen from dermal fibroblasts. Pirfenidone has demonstrated efficiency in the treatment of disordered collagen production when applied topically. Due to a similar mechanism of action, we also hypothesize that a similar medication, nintedanib, might have similar applications. We also propose that a liposomal technology may assist in the penetration of nintedanib and enhance its clinical effects.
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spelling pubmed-94805932022-09-17 New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring? Cristodor, Patricia Liana Nechifor, Alexandru Fotea, Silvia Nadasdy, Thomas Bahloul, Yousef Nicolescu, Alin Codrut Tatu, Alin Laurentiu Int J Gen Med Hypothesis There are a wide variety of disfiguring dermatological conditions whose pathologic substrate is represented by the unwanted deposition of collagen from dermal fibroblasts. Pirfenidone has demonstrated efficiency in the treatment of disordered collagen production when applied topically. Due to a similar mechanism of action, we also hypothesize that a similar medication, nintedanib, might have similar applications. We also propose that a liposomal technology may assist in the penetration of nintedanib and enhance its clinical effects. Dove 2022-09-12 /pmc/articles/PMC9480593/ /pubmed/36118185 http://dx.doi.org/10.2147/IJGM.S377073 Text en © 2022 Cristodor et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Hypothesis
Cristodor, Patricia Liana
Nechifor, Alexandru
Fotea, Silvia
Nadasdy, Thomas
Bahloul, Yousef
Nicolescu, Alin Codrut
Tatu, Alin Laurentiu
New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?
title New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?
title_full New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?
title_fullStr New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?
title_full_unstemmed New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?
title_short New Antifibroblastic Medication in Dermatology: Could Nintedanib Treat Scarring?
title_sort new antifibroblastic medication in dermatology: could nintedanib treat scarring?
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480593/
https://www.ncbi.nlm.nih.gov/pubmed/36118185
http://dx.doi.org/10.2147/IJGM.S377073
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