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Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients
BACKGROUND: Dengue fever is a mosquito borne disease commonly manifest leucopoenia and thrombocytopenia. Dengue fever and its complications like bleeding manifestation can be life threatening. This study was conducted to study the effect of doxycycline and doxycycline with carica papaya on thrombocy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480729/ https://www.ncbi.nlm.nih.gov/pubmed/36119216 http://dx.doi.org/10.4103/jfmpc.jfmpc_53_22 |
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author | Pambhar, Vivek Mathur, Navgeet Mehta, Amit Mathur, Medha Kumawat, Dal Chand Mangalia, Ravi Verma, Anjana Patyal, Ashish |
author_facet | Pambhar, Vivek Mathur, Navgeet Mehta, Amit Mathur, Medha Kumawat, Dal Chand Mangalia, Ravi Verma, Anjana Patyal, Ashish |
author_sort | Pambhar, Vivek |
collection | PubMed |
description | BACKGROUND: Dengue fever is a mosquito borne disease commonly manifest leucopoenia and thrombocytopenia. Dengue fever and its complications like bleeding manifestation can be life threatening. This study was conducted to study the effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopoenia in acute dengue fever patients. METHODS: This case control study was conducted amongst the patients suffering from dengue fever with thrombocytopenia. Cases were dengue patients with thrombocytopenia and leucopenia both. Controls were dengue patients with thrombocytopenia with normal leukocyte count. An effect of doxycycline and doxycycline with carica papaya was observed on platelet and leukocyte counts at baseline and first, second, fourth, and seventh day in cases and comparison was done. RESULTS: The maximum improvement in mean platelet count and leukocyte count was observed in doxycycline with carica papaya group followed by doxycycline alone group followed by controls (conservative treatment) in decreasing order on day 4(th) and 7(th) day of admission. Reduced hospital stay was also in the same order. CONCLUSION: The study results indicate that doxycycline and carica papaya are useful modality to improve leucopenia and thrombocytopenia in dengue patients and to minimize hospital stay. |
format | Online Article Text |
id | pubmed-9480729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-94807292022-09-17 Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients Pambhar, Vivek Mathur, Navgeet Mehta, Amit Mathur, Medha Kumawat, Dal Chand Mangalia, Ravi Verma, Anjana Patyal, Ashish J Family Med Prim Care Original Article BACKGROUND: Dengue fever is a mosquito borne disease commonly manifest leucopoenia and thrombocytopenia. Dengue fever and its complications like bleeding manifestation can be life threatening. This study was conducted to study the effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopoenia in acute dengue fever patients. METHODS: This case control study was conducted amongst the patients suffering from dengue fever with thrombocytopenia. Cases were dengue patients with thrombocytopenia and leucopenia both. Controls were dengue patients with thrombocytopenia with normal leukocyte count. An effect of doxycycline and doxycycline with carica papaya was observed on platelet and leukocyte counts at baseline and first, second, fourth, and seventh day in cases and comparison was done. RESULTS: The maximum improvement in mean platelet count and leukocyte count was observed in doxycycline with carica papaya group followed by doxycycline alone group followed by controls (conservative treatment) in decreasing order on day 4(th) and 7(th) day of admission. Reduced hospital stay was also in the same order. CONCLUSION: The study results indicate that doxycycline and carica papaya are useful modality to improve leucopenia and thrombocytopenia in dengue patients and to minimize hospital stay. Wolters Kluwer - Medknow 2022-06 2022-06-30 /pmc/articles/PMC9480729/ /pubmed/36119216 http://dx.doi.org/10.4103/jfmpc.jfmpc_53_22 Text en Copyright: © 2022 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Pambhar, Vivek Mathur, Navgeet Mehta, Amit Mathur, Medha Kumawat, Dal Chand Mangalia, Ravi Verma, Anjana Patyal, Ashish Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients |
title | Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients |
title_full | Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients |
title_fullStr | Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients |
title_full_unstemmed | Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients |
title_short | Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients |
title_sort | effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480729/ https://www.ncbi.nlm.nih.gov/pubmed/36119216 http://dx.doi.org/10.4103/jfmpc.jfmpc_53_22 |
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