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PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance

The PBRM1 subunit of the PBAF (SWI/SNF) chromatin remodeling complex is mutated in ∼40% of clear cell renal cancers. PBRM1 loss has been implicated in responses to immunotherapy in renal cancer, but the mechanism is unclear. DNA damage-induced inflammatory signaling is an important factor determinin...

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Detalles Bibliográficos
Autores principales:	Feng, Hugang, Lane, Karen A., Roumeliotis, Theodoros I., Jeggo, Penny A., Somaiah, Navita, Choudhary, Jyoti S., Downs, Jessica A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480851/ https://www.ncbi.nlm.nih.gov/pubmed/35902118 http://dx.doi.org/10.1101/gad.349249.121

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