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Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review

OBJECTIVE: Globally, suicide represents the second leading cause of death in young people aged 15–29 years for both sexes, after traffic accidents. Suicide occurs not only in high‐income countries, in high‐income countries but it is a global phenomenon in all regions of the world and it represents a...

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Autores principales: Zanghì, Emanuele, Corallo, Francesco, Lo Buono, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480894/
https://www.ncbi.nlm.nih.gov/pubmed/35943210
http://dx.doi.org/10.1002/brb3.2711
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author Zanghì, Emanuele
Corallo, Francesco
Lo Buono, Viviana
author_facet Zanghì, Emanuele
Corallo, Francesco
Lo Buono, Viviana
author_sort Zanghì, Emanuele
collection PubMed
description OBJECTIVE: Globally, suicide represents the second leading cause of death in young people aged 15–29 years for both sexes, after traffic accidents. Suicide occurs not only in high‐income countries, in high‐income countries but it is a global phenomenon in all regions of the world and it represents a serious public health problem. METHOD: This review was conducted on studies focused on white matter alterations in people who have attempted or thought about suicide. We searched PubMed and Scopus databases and screened references of included studies and reviewed articles for additional citations. From the initial 21 publications, we included only 12 studies that met search criteria and described the association between white matter alterations and suicide. RESULTS: White matter alterations in suicidal behaviors were found in the prefrontal cortex, orbitofrontal cortex, internal capsule, corpus callosum, and default mode networks, which are critical cerebral areas involved in emotion processing and regulation, decision‐making, executive functions, and empathy. CONCLUSIONS: White matter alteration in cerebral areas involving high cognitive process and emotional regulation to confer a heightened vulnerability for suicidal behavior. Suicide is a complex process ranging from suicidal ideation to planning, attempting, or committing suicide. The identification of abnormalities in underlying neural circuitry may help delineate the neurobiological basis for suicide risk.
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spelling pubmed-94808942022-09-28 Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review Zanghì, Emanuele Corallo, Francesco Lo Buono, Viviana Brain Behav Original Articles OBJECTIVE: Globally, suicide represents the second leading cause of death in young people aged 15–29 years for both sexes, after traffic accidents. Suicide occurs not only in high‐income countries, in high‐income countries but it is a global phenomenon in all regions of the world and it represents a serious public health problem. METHOD: This review was conducted on studies focused on white matter alterations in people who have attempted or thought about suicide. We searched PubMed and Scopus databases and screened references of included studies and reviewed articles for additional citations. From the initial 21 publications, we included only 12 studies that met search criteria and described the association between white matter alterations and suicide. RESULTS: White matter alterations in suicidal behaviors were found in the prefrontal cortex, orbitofrontal cortex, internal capsule, corpus callosum, and default mode networks, which are critical cerebral areas involved in emotion processing and regulation, decision‐making, executive functions, and empathy. CONCLUSIONS: White matter alteration in cerebral areas involving high cognitive process and emotional regulation to confer a heightened vulnerability for suicidal behavior. Suicide is a complex process ranging from suicidal ideation to planning, attempting, or committing suicide. The identification of abnormalities in underlying neural circuitry may help delineate the neurobiological basis for suicide risk. John Wiley and Sons Inc. 2022-08-09 /pmc/articles/PMC9480894/ /pubmed/35943210 http://dx.doi.org/10.1002/brb3.2711 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zanghì, Emanuele
Corallo, Francesco
Lo Buono, Viviana
Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review
title Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review
title_full Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review
title_fullStr Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review
title_full_unstemmed Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review
title_short Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review
title_sort diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: a descriptive literature review
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480894/
https://www.ncbi.nlm.nih.gov/pubmed/35943210
http://dx.doi.org/10.1002/brb3.2711
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