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A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease

AIM: This article aims to study the benefits and disadvantages of stem cell therapy, especially for patients who have dementia. METHODS: The databases PubMed, Google Scholar, and the National Library of Medicine were searched for literature. All papers on Alzheimer's disease, Lewy body dementia...

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Autores principales: Pradhan, Aishwarya Umesh, Uwishema, Olivier, Onyeaka, Helen, Adanur, Irem, Dost, Burhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480940/
https://www.ncbi.nlm.nih.gov/pubmed/35971625
http://dx.doi.org/10.1002/brb3.2740
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author Pradhan, Aishwarya Umesh
Uwishema, Olivier
Onyeaka, Helen
Adanur, Irem
Dost, Burhan
author_facet Pradhan, Aishwarya Umesh
Uwishema, Olivier
Onyeaka, Helen
Adanur, Irem
Dost, Burhan
author_sort Pradhan, Aishwarya Umesh
collection PubMed
description AIM: This article aims to study the benefits and disadvantages of stem cell therapy, especially for patients who have dementia. METHODS: The databases PubMed, Google Scholar, and the National Library of Medicine were searched for literature. All papers on Alzheimer's disease, Lewy body dementia, Parkinson's disease, stem cell therapy, and its effect on dementia treatment were considered. RESULTS: Stem cell treatment has demonstrated promising outcomes in animal studies by positively modifying the degenerative alterations in dementia. However, it is not without drawbacks, such as ethical concerns while using embryonic stem cells and the danger of developing cancer if the cells undergo uncontrolled differentiation. CONCLUSION: Although stem cell therapy has its risks, it has the potential to be a viable therapeutic option for patients with dementia if developed appropriately. Hence, more research and clinical trials are needed to establish its efficacy in this context.
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spelling pubmed-94809402022-09-28 A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease Pradhan, Aishwarya Umesh Uwishema, Olivier Onyeaka, Helen Adanur, Irem Dost, Burhan Brain Behav Reviews AIM: This article aims to study the benefits and disadvantages of stem cell therapy, especially for patients who have dementia. METHODS: The databases PubMed, Google Scholar, and the National Library of Medicine were searched for literature. All papers on Alzheimer's disease, Lewy body dementia, Parkinson's disease, stem cell therapy, and its effect on dementia treatment were considered. RESULTS: Stem cell treatment has demonstrated promising outcomes in animal studies by positively modifying the degenerative alterations in dementia. However, it is not without drawbacks, such as ethical concerns while using embryonic stem cells and the danger of developing cancer if the cells undergo uncontrolled differentiation. CONCLUSION: Although stem cell therapy has its risks, it has the potential to be a viable therapeutic option for patients with dementia if developed appropriately. Hence, more research and clinical trials are needed to establish its efficacy in this context. John Wiley and Sons Inc. 2022-08-15 /pmc/articles/PMC9480940/ /pubmed/35971625 http://dx.doi.org/10.1002/brb3.2740 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Pradhan, Aishwarya Umesh
Uwishema, Olivier
Onyeaka, Helen
Adanur, Irem
Dost, Burhan
A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease
title A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease
title_full A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease
title_fullStr A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease
title_full_unstemmed A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease
title_short A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease
title_sort review of stem cell therapy: an emerging treatment for dementia in alzheimer's and parkinson's disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9480940/
https://www.ncbi.nlm.nih.gov/pubmed/35971625
http://dx.doi.org/10.1002/brb3.2740
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