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Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy
OBJECTIVE: The objective was to analyze the clinical characteristics and pathological characteristics of sural biopsy in nitrous oxide (N(2)O) -induced peripheral neuropathy. METHODS: We recruited 18 patients with N(2)O abuse-induced neurological disorders and reported their demographic data, clinic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481023/ https://www.ncbi.nlm.nih.gov/pubmed/36112660 http://dx.doi.org/10.1371/journal.pone.0274765 |
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author | Wang, Qian Duan, Xiaohui Dong, Mingrui Sun, Shaojie Zhang, Pan Liu, Fang Wang, Li Wang, Renbin |
author_facet | Wang, Qian Duan, Xiaohui Dong, Mingrui Sun, Shaojie Zhang, Pan Liu, Fang Wang, Li Wang, Renbin |
author_sort | Wang, Qian |
collection | PubMed |
description | OBJECTIVE: The objective was to analyze the clinical characteristics and pathological characteristics of sural biopsy in nitrous oxide (N(2)O) -induced peripheral neuropathy. METHODS: We recruited 18 patients with N(2)O abuse-induced neurological disorders and reported their demographic data, clinical manifestations, laboratory examinations, and nerve conduction studies. Seven patients underwent sural nerve biopsy pathologic examination. RESULTS: All 18 patients had polyneuropathy, the nerve conduction results showed significant reductions in motor and sensory amplitudes, slowing of conduction velocities, and prolongation of latencies in most tested nerves compared to the controls. Toluidine blue staining of semi-thin sections of sural nerve biopsy showed decreased myelinated nerve fiber density, increased thin myelinated nerve fiber density, and axonal regeneration. Electron microscopy showed axonal degeneration and nerve regeneration. CONCLUSION: The main manifestations of peripheral nerve damage caused by the abuse of N(2)O are lower limb weakness and distal sensory disorder. The nerve conduction study results demonstrated that mixed axonal and demyelinating neuropathy was the most common type of neuropathy. Sural biopsy showed the main pathological change was chronic axonal degeneration. |
format | Online Article Text |
id | pubmed-9481023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94810232022-09-17 Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy Wang, Qian Duan, Xiaohui Dong, Mingrui Sun, Shaojie Zhang, Pan Liu, Fang Wang, Li Wang, Renbin PLoS One Research Article OBJECTIVE: The objective was to analyze the clinical characteristics and pathological characteristics of sural biopsy in nitrous oxide (N(2)O) -induced peripheral neuropathy. METHODS: We recruited 18 patients with N(2)O abuse-induced neurological disorders and reported their demographic data, clinical manifestations, laboratory examinations, and nerve conduction studies. Seven patients underwent sural nerve biopsy pathologic examination. RESULTS: All 18 patients had polyneuropathy, the nerve conduction results showed significant reductions in motor and sensory amplitudes, slowing of conduction velocities, and prolongation of latencies in most tested nerves compared to the controls. Toluidine blue staining of semi-thin sections of sural nerve biopsy showed decreased myelinated nerve fiber density, increased thin myelinated nerve fiber density, and axonal regeneration. Electron microscopy showed axonal degeneration and nerve regeneration. CONCLUSION: The main manifestations of peripheral nerve damage caused by the abuse of N(2)O are lower limb weakness and distal sensory disorder. The nerve conduction study results demonstrated that mixed axonal and demyelinating neuropathy was the most common type of neuropathy. Sural biopsy showed the main pathological change was chronic axonal degeneration. Public Library of Science 2022-09-16 /pmc/articles/PMC9481023/ /pubmed/36112660 http://dx.doi.org/10.1371/journal.pone.0274765 Text en © 2022 Wang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Wang, Qian Duan, Xiaohui Dong, Mingrui Sun, Shaojie Zhang, Pan Liu, Fang Wang, Li Wang, Renbin Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy |
title | Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy |
title_full | Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy |
title_fullStr | Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy |
title_full_unstemmed | Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy |
title_short | Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy |
title_sort | clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481023/ https://www.ncbi.nlm.nih.gov/pubmed/36112660 http://dx.doi.org/10.1371/journal.pone.0274765 |
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