Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation

The concept of exploiting tumor intrinsic deficiencies in DNA damage repair mechanisms by inhibiting compensatory DNA repair pathways is well established. For example, ATM-deficient cells show increased sensitivity to the ATR inhibitor ceralasertib. DNA damage response (DDR)-deficient cells are also...

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Detalles Bibliográficos
Autores principales: Lopez-Pelaez, Marta, Young, Lucy, Vazquez-Chantada, Mercedes, Nelson, Nadine, Durant, Steve, Wilkinson, Robert W., Poon, Edmund, Gaspar, Miguel, Valge-Archer, Viia, Smith, Paul, Dovedi, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481087/
https://www.ncbi.nlm.nih.gov/pubmed/36117525
http://dx.doi.org/10.1080/2162402X.2022.2117321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481087/
https://www.ncbi.nlm.nih.gov/pubmed/36117525
http://dx.doi.org/10.1080/2162402X.2022.2117321

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