Design, synthesis and biological evaluation of 2,4-pyrimidinediamine derivatives as ALK and HDACs dual inhibitors for the treatment of ALK addicted cancer

Simultaneous inhibition of histone deacetylases (HDACs) and anaplastic lymphoma kinase (ALK) could enhance therapeutic activity against ALK addicted cancer cells. Herein, a new series of 2,4-pyrimidinediamine derivatives as ALK and HDACs dual inhibitors were designed, synthesised and evaluated. Comp...

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Detalles Bibliográficos
Autores principales: Guo, Dafeng, Yu, Yu, Long, Binyu, Deng, Ping, Ran, Dongzhi, Han, Lei, Zheng, Jiecheng, Gan, Zongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481106/
https://www.ncbi.nlm.nih.gov/pubmed/36100230
http://dx.doi.org/10.1080/14756366.2022.2121822

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