Activation of TrkB-Akt signaling rescues deficits in a mouse model of SCA6

Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease resulting in motor coordination deficits and cerebellar pathology. Expression of brain-derived neurotrophic factor (BDNF) is reduced in postmortem tissue from SCA6 patients. Here, we show that levels of cerebellar BDNF and its recep...

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Detalles Bibliográficos
Autores principales: Cook, Anna A., Jayabal, Sriram, Sheng, Jacky, Fields, Eviatar, Leung, Tsz Chui Sophia, Quilez, Sabrina, McNicholas, Eileen, Lau, Lois, Huang, Shixia, Watt, Alanna J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481119/
https://www.ncbi.nlm.nih.gov/pubmed/36112675
http://dx.doi.org/10.1126/sciadv.abh3260

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