Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actions

Using a genome-wide CRISPR screen, we identified CDK9, DHODH, and PRMT5 as synthetic lethal partners with gilteritinib treatment in fms-like tyrosine kinase 3 (FLT3)–internal tandem duplication (ITD) acute myeloid leukemia (AML) and genetically and pharmacologically validated their roles in gilterit...

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Detalles Bibliográficos
Autores principales: Zhang, Pu, Brinton, Lindsey T., Gharghabi, Mehdi, Sher, Steven, Williams, Katie, Cannon, Matthew, Walker, Janek S., Canfield, Daniel, Beaver, Larry, Cempre, Casey B., Phillips, Hannah, Chen, Xuyong, Yan, Pearlly, Lehman, Amy, Scherle, Peggy, Wang, Min, Vaddi, Kris, Baiocchi, Robert, Wang, Ruoning, Sampath, Deepa, Alinari, Lapo, Blachly, James S., Lapalombella, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481139/
https://www.ncbi.nlm.nih.gov/pubmed/36112677
http://dx.doi.org/10.1126/sciadv.abp9005

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