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Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses

Flaviviruses are arthropod-borne viruses (arboviruses) that have been recently considered among the significant public health problems in defined geographical regions. In this line, there have been vaccines approved for some flaviviruses including dengue virus (DENV), Japanese encephalitis virus (JE...

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Autores principales: Shoushtari, Mohammad, Roohvand, Farzin, Salehi-Vaziri, Mostafa, Arashkia, Arash, Bakhshi, Hasan, Azadmanesh, Kayhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481145/
https://www.ncbi.nlm.nih.gov/pubmed/35714271
http://dx.doi.org/10.1080/21645515.2022.2079323
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author Shoushtari, Mohammad
Roohvand, Farzin
Salehi-Vaziri, Mostafa
Arashkia, Arash
Bakhshi, Hasan
Azadmanesh, Kayhan
author_facet Shoushtari, Mohammad
Roohvand, Farzin
Salehi-Vaziri, Mostafa
Arashkia, Arash
Bakhshi, Hasan
Azadmanesh, Kayhan
author_sort Shoushtari, Mohammad
collection PubMed
description Flaviviruses are arthropod-borne viruses (arboviruses) that have been recently considered among the significant public health problems in defined geographical regions. In this line, there have been vaccines approved for some flaviviruses including dengue virus (DENV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and tick-borne encephalitis virus (TBEV), although the efficiency of such vaccines thought to be questionable. Surprisingly, there are no effective vaccine for many other hazardous flaviviruses, including West Nile and Zika viruses. Furthermore, in spite of approved vaccines for some flaviviruses, for example DENV, alternative prophylactic vaccines seem to be still needed for the protection of a broader population, and it originates from the unsatisfying safety, and the efficacy of vaccines that have been introduced. Thus, adenovirus vector-based vaccine candidates are suggested to be effective, safe, and reliable. Interestingly, recent widespread use of adenovirus vector-based vaccines for the COVID-19 pandemic have highlighted the importance and feasibility of their widespread application. In this review, the applicability of adenovirus vector-based vaccines, as promising approaches to harness the diseases caused by Flaviviruses, is discussed.
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spelling pubmed-94811452022-09-17 Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses Shoushtari, Mohammad Roohvand, Farzin Salehi-Vaziri, Mostafa Arashkia, Arash Bakhshi, Hasan Azadmanesh, Kayhan Hum Vaccin Immunother Novel Vaccines – Review Flaviviruses are arthropod-borne viruses (arboviruses) that have been recently considered among the significant public health problems in defined geographical regions. In this line, there have been vaccines approved for some flaviviruses including dengue virus (DENV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and tick-borne encephalitis virus (TBEV), although the efficiency of such vaccines thought to be questionable. Surprisingly, there are no effective vaccine for many other hazardous flaviviruses, including West Nile and Zika viruses. Furthermore, in spite of approved vaccines for some flaviviruses, for example DENV, alternative prophylactic vaccines seem to be still needed for the protection of a broader population, and it originates from the unsatisfying safety, and the efficacy of vaccines that have been introduced. Thus, adenovirus vector-based vaccine candidates are suggested to be effective, safe, and reliable. Interestingly, recent widespread use of adenovirus vector-based vaccines for the COVID-19 pandemic have highlighted the importance and feasibility of their widespread application. In this review, the applicability of adenovirus vector-based vaccines, as promising approaches to harness the diseases caused by Flaviviruses, is discussed. Taylor & Francis 2022-06-17 /pmc/articles/PMC9481145/ /pubmed/35714271 http://dx.doi.org/10.1080/21645515.2022.2079323 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Novel Vaccines – Review
Shoushtari, Mohammad
Roohvand, Farzin
Salehi-Vaziri, Mostafa
Arashkia, Arash
Bakhshi, Hasan
Azadmanesh, Kayhan
Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses
title Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses
title_full Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses
title_fullStr Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses
title_full_unstemmed Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses
title_short Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses
title_sort adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses
topic Novel Vaccines – Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481145/
https://www.ncbi.nlm.nih.gov/pubmed/35714271
http://dx.doi.org/10.1080/21645515.2022.2079323
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