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Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis

Psoriasis is an immune-mediated chronic inflammatory skin disease caused by a combination of environmental incentives, polygenic genetic control, and immune regulation. The inflammation-related gene absent in melanoma 2 (AIM2) was identified as a susceptibility gene for psoriasis. AIM2 inflammasome...

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Autores principales: Wang, Jieyi, Gao, Jing, Huang, Cong, Jeong, Sohyun, Ko, Randy, Shen, Xue, Chen, Chaofeng, Zhong, Weilong, Zou, Yanfen, Yu, Bo, Shen, Changbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481235/
https://www.ncbi.nlm.nih.gov/pubmed/36118867
http://dx.doi.org/10.3389/fgene.2022.929162
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author Wang, Jieyi
Gao, Jing
Huang, Cong
Jeong, Sohyun
Ko, Randy
Shen, Xue
Chen, Chaofeng
Zhong, Weilong
Zou, Yanfen
Yu, Bo
Shen, Changbing
author_facet Wang, Jieyi
Gao, Jing
Huang, Cong
Jeong, Sohyun
Ko, Randy
Shen, Xue
Chen, Chaofeng
Zhong, Weilong
Zou, Yanfen
Yu, Bo
Shen, Changbing
author_sort Wang, Jieyi
collection PubMed
description Psoriasis is an immune-mediated chronic inflammatory skin disease caused by a combination of environmental incentives, polygenic genetic control, and immune regulation. The inflammation-related gene absent in melanoma 2 (AIM2) was identified as a susceptibility gene for psoriasis. AIM2 inflammasome formed from the combination of AIM2, PYD-linked apoptosis-associated speck-like protein (ASC) and Caspase-1 promotes the maturation and release of inflammatory cytokines such as IL-1β and IL-18, and triggers an inflammatory response. Studies showed the genetic and epigenetic associations between AIM2 gene and psoriasis. AIM2 gene has an essential role in the occurrence and development of psoriasis, and the inhibitors of AIM2 inflammasome will be new therapeutic targets for psoriasis. In this review, we summarized the roles of the AIM2 gene and AIM2 inflammasome in pathogenesis and treatment of psoriasis, hopefully providing a better understanding and new insight into the roles of AIM2 gene and AIM2 inflammasome in psoriasis.
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spelling pubmed-94812352022-09-17 Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis Wang, Jieyi Gao, Jing Huang, Cong Jeong, Sohyun Ko, Randy Shen, Xue Chen, Chaofeng Zhong, Weilong Zou, Yanfen Yu, Bo Shen, Changbing Front Genet Genetics Psoriasis is an immune-mediated chronic inflammatory skin disease caused by a combination of environmental incentives, polygenic genetic control, and immune regulation. The inflammation-related gene absent in melanoma 2 (AIM2) was identified as a susceptibility gene for psoriasis. AIM2 inflammasome formed from the combination of AIM2, PYD-linked apoptosis-associated speck-like protein (ASC) and Caspase-1 promotes the maturation and release of inflammatory cytokines such as IL-1β and IL-18, and triggers an inflammatory response. Studies showed the genetic and epigenetic associations between AIM2 gene and psoriasis. AIM2 gene has an essential role in the occurrence and development of psoriasis, and the inhibitors of AIM2 inflammasome will be new therapeutic targets for psoriasis. In this review, we summarized the roles of the AIM2 gene and AIM2 inflammasome in pathogenesis and treatment of psoriasis, hopefully providing a better understanding and new insight into the roles of AIM2 gene and AIM2 inflammasome in psoriasis. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9481235/ /pubmed/36118867 http://dx.doi.org/10.3389/fgene.2022.929162 Text en Copyright © 2022 Wang, Gao, Huang, Jeong, Ko, Shen, Chen, Zhong, Zou, Yu and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wang, Jieyi
Gao, Jing
Huang, Cong
Jeong, Sohyun
Ko, Randy
Shen, Xue
Chen, Chaofeng
Zhong, Weilong
Zou, Yanfen
Yu, Bo
Shen, Changbing
Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
title Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
title_full Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
title_fullStr Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
title_full_unstemmed Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
title_short Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
title_sort roles of aim2 gene and aim2 inflammasome in the pathogenesis and treatment of psoriasis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481235/
https://www.ncbi.nlm.nih.gov/pubmed/36118867
http://dx.doi.org/10.3389/fgene.2022.929162
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