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Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to a global health outbreak known as the COVID-19 pandemic which has been lasting since March 2020. Vaccine became accessible to people only at the beginning of 2021 which greatly helped reducing the mortality rate and severity of COVI...

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Autores principales: Pavel-Tanasa, Mariana, Constantinescu, Daniela, Cianga, Corina Maria, Anisie, Ecaterina, Mereuta, Ana Irina, Tuchilus, Cristina Gabriela, Cianga, Petru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481237/
https://www.ncbi.nlm.nih.gov/pubmed/36119038
http://dx.doi.org/10.3389/fimmu.2022.1000006
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author Pavel-Tanasa, Mariana
Constantinescu, Daniela
Cianga, Corina Maria
Anisie, Ecaterina
Mereuta, Ana Irina
Tuchilus, Cristina Gabriela
Cianga, Petru
author_facet Pavel-Tanasa, Mariana
Constantinescu, Daniela
Cianga, Corina Maria
Anisie, Ecaterina
Mereuta, Ana Irina
Tuchilus, Cristina Gabriela
Cianga, Petru
author_sort Pavel-Tanasa, Mariana
collection PubMed
description Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to a global health outbreak known as the COVID-19 pandemic which has been lasting since March 2020. Vaccine became accessible to people only at the beginning of 2021 which greatly helped reducing the mortality rate and severity of COVID-19 infection afterwards. The efficacy of vaccines was not fully known and studies documenting the immune responses following vaccination are continuing to emerge. Recent evidence indicate that natural infection prior vaccination may improve the antibody and cellular immune responses, while little is known about the factors influencing those processes. Here we investigated the antibody responses following BNT162b2 vaccination in relation to previous-infection status and age, and searched for possible biomarkers associated with the observed changes in immune responses. We found that the previous-infection status caused at least 8-times increase in the antibody titres, effect that was weaker in people over 60 years old and unaltered by the vitamin D serum levels. Furthermore, we identified adiponectin to positively associate with antibody responses and negatively correlate with pro-inflammatory molecules (MCP-1, factor D, CRP, PAI-1), especially in previously-infected individuals.
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spelling pubmed-94812372022-09-17 Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years Pavel-Tanasa, Mariana Constantinescu, Daniela Cianga, Corina Maria Anisie, Ecaterina Mereuta, Ana Irina Tuchilus, Cristina Gabriela Cianga, Petru Front Immunol Immunology Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to a global health outbreak known as the COVID-19 pandemic which has been lasting since March 2020. Vaccine became accessible to people only at the beginning of 2021 which greatly helped reducing the mortality rate and severity of COVID-19 infection afterwards. The efficacy of vaccines was not fully known and studies documenting the immune responses following vaccination are continuing to emerge. Recent evidence indicate that natural infection prior vaccination may improve the antibody and cellular immune responses, while little is known about the factors influencing those processes. Here we investigated the antibody responses following BNT162b2 vaccination in relation to previous-infection status and age, and searched for possible biomarkers associated with the observed changes in immune responses. We found that the previous-infection status caused at least 8-times increase in the antibody titres, effect that was weaker in people over 60 years old and unaltered by the vitamin D serum levels. Furthermore, we identified adiponectin to positively associate with antibody responses and negatively correlate with pro-inflammatory molecules (MCP-1, factor D, CRP, PAI-1), especially in previously-infected individuals. Frontiers Media S.A. 2022-09-02 /pmc/articles/PMC9481237/ /pubmed/36119038 http://dx.doi.org/10.3389/fimmu.2022.1000006 Text en Copyright © 2022 Pavel-Tanasa, Constantinescu, Cianga, Anisie, Mereuta, Tuchilus and Cianga https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Pavel-Tanasa, Mariana
Constantinescu, Daniela
Cianga, Corina Maria
Anisie, Ecaterina
Mereuta, Ana Irina
Tuchilus, Cristina Gabriela
Cianga, Petru
Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years
title Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years
title_full Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years
title_fullStr Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years
title_full_unstemmed Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years
title_short Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years
title_sort adipokines, and not vitamin d, associate with antibody immune responses following dual bnt162b2 vaccination within individuals younger than 60 years
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481237/
https://www.ncbi.nlm.nih.gov/pubmed/36119038
http://dx.doi.org/10.3389/fimmu.2022.1000006
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