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IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model

The anti-inflammatory cytokine interleukin-37 (IL-37) belongs to the IL-1 family but is not expressed in mice. We used a human IL-37 (hIL-37tg) expressing mouse, which has been subjected to various models of local and systemic inflammation as well as immunological challenges. Previous studies reveal...

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Detalles Bibliográficos
Autores principales:	Lonnemann, Niklas, Hosseini, Shirin, Ohm, Melanie, Geffers, Robert, Hiller, Karsten, Dinarello, Charles A, Korte, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481244/ https://www.ncbi.nlm.nih.gov/pubmed/36040311 http://dx.doi.org/10.7554/eLife.75889

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