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Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy
De novo mutations in voltage- and ligand-gated channels have been associated with an increasing number of cases of developmental and epileptic encephalopathies, which often fail to respond to classic antiseizure medications. Here, we examine two knock-in mouse models replicating de novo sequence var...
Autores principales: | Merseburg, Andrea, Kasemir, Jacquelin, Buss, Eric W, Leroy, Felix, Bock, Tobias, Porro, Alessandro, Barnett, Anastasia, Tröder, Simon E, Engeland, Birgit, Stockebrand, Malte, Moroni, Anna, Siegelbaum, Steven A, Isbrandt, Dirk, Santoro, Bina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481245/ https://www.ncbi.nlm.nih.gov/pubmed/35972069 http://dx.doi.org/10.7554/eLife.70826 |
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