Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

De novo mutations in voltage- and ligand-gated channels have been associated with an increasing number of cases of developmental and epileptic encephalopathies, which often fail to respond to classic antiseizure medications. Here, we examine two knock-in mouse models replicating de novo sequence var...

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Detalles Bibliográficos
Autores principales: Merseburg, Andrea, Kasemir, Jacquelin, Buss, Eric W, Leroy, Felix, Bock, Tobias, Porro, Alessandro, Barnett, Anastasia, Tröder, Simon E, Engeland, Birgit, Stockebrand, Malte, Moroni, Anna, Siegelbaum, Steven A, Isbrandt, Dirk, Santoro, Bina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481245/
https://www.ncbi.nlm.nih.gov/pubmed/35972069
http://dx.doi.org/10.7554/eLife.70826

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