Cargando…

Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF-κB Signaling Pathways

Intervertebral disc degeneration (IDD) is the leading cause of low back pain (LBP). However, effective therapeutic drugs for IDD remain to be further explored. Inflammatory cytokines play a pivotal role in the onset and progression of IDD. Dihydroartemisinin (DHA) has been well reported to have powe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, Zhiheng, Su, Deying, Liu, Hengyu, Xu, Caixia, Wu, Jinna, Chen, Yuyu, Guo, Weimin, Zhang, Shun, Li, Zhuling, Ke, Xiaona, Wang, Tingting, Zhou, Taifeng, Su, Peiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481359/ https://www.ncbi.nlm.nih.gov/pubmed/36120596 http://dx.doi.org/10.1155/2022/8672969

Ejemplares similares

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration
por: Wu, Jinna, et al.
Publicado: (2022)

Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution
por: Zhou, Taifeng, et al.
Publicado: (2023)

Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis
por: Chen, Yuyu, et al.
Publicado: (2022)

Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf
por: Chen, Yuyu, et al.
Publicado: (2023)

Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling
por: Wu, Chengzhi, et al.
Publicado: (2023)

Dual novel mutations in SLC26A2 in two siblings with multiple epiphyseal dysplasia 4 from a Chinese family: a case report
por: Zhou, Taifeng, et al.
Publicado: (2018)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Genetic Therapy for Intervertebral Disc Degeneration
por: Roh, Eun Ji, et al.
Publicado: (2021)

Estrogen promotes the onset and development of idiopathic scoliosis via disproportionate endochondral ossification of the anterior and posterior column in a bipedal rat model
por: Zheng, Shuhui, et al.
Publicado: (2018)

Pathomechanism of intervertebral disc degeneration
por: Oichi, Takeshi, et al.
Publicado: (2020)

Treatment of Intervertebral Disc Degeneration
por: Xin, Jingguo, et al.
Publicado: (2022)

Macrophages and Intervertebral Disc Degeneration
por: Koroth, Jinsha, et al.
Publicado: (2023)

Effects of bone cement on intervertebral disc degeneration
por: ZHAO, HUI, et al.
Publicado: (2014)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Intervertebral Disc Biology: Genetic Basis of Disc Degeneration
por: Munir, Sabrina, et al.
Publicado: (2018)

Angiogenesis in the degeneration of the lumbar intervertebral disc
por: David, Gh, et al.
Publicado: (2010)

Intervertebral disc degeneration therapies in human
por: Richardson, Stephen M
Publicado: (2015)

Genetic factors in intervertebral disc degeneration
por: Feng, Yi, et al.
Publicado: (2016)

The Role of Adipokines in Intervertebral Disc Degeneration
por: Sharma, Anirudh
Publicado: (2018)

Molecular Mechanisms of Intervertebral Disc Degeneration
por: Rider, Sean M., et al.
Publicado: (2018)

Cervical intervertebral disc degeneration and dizziness
por: Liu, Tang-Hua, et al.
Publicado: (2021)

The Proteolysis of ECM in Intervertebral Disc Degeneration
por: Liang, Huaizhen, et al.
Publicado: (2022)

The role of ferroptosis in intervertebral disc degeneration
por: Fan, Chunyang, et al.
Publicado: (2023)

Role of Necroptosis in Intervertebral Disc Degeneration
por: Khaleque, Md Abdul, et al.
Publicado: (2023)

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway
por: Liu, Zi-Miao, et al.
Publicado: (2021)

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
por: Millward-Sadler, S Jane, et al.
Publicado: (2009)

Astragaloside IV attenuates IL-1β-induced intervertebral disc degeneration through inhibition of the NF-κB pathway
por: Tian, Yueyang, et al.
Publicado: (2022)

Bovine explant model of degeneration of the intervertebral disc
por: Roberts, Sally, et al.
Publicado: (2008)

Intervertebral disc degeneration: biological and biomechanical factors
por: An, Howard S., et al.
Publicado: (2006)

Stem cell horizons in intervertebral disc degeneration
por: Ciacci, Joseph, et al.
Publicado: (2009)

Notochord Cells in Intervertebral Disc Development and Degeneration
por: McCann, Matthew R., et al.
Publicado: (2016)

Inflammatory profiles in canine intervertebral disc degeneration
por: Willems, Nicole, et al.
Publicado: (2016)

Current Understanding of the Genetics of Intervertebral Disc Degeneration
por: Dickinson, Peter J., et al.
Publicado: (2020)

Adrenoceptor Expression during Intervertebral Disc Degeneration
por: Kupka, Johannes, et al.
Publicado: (2020)

Mitochondrial quality control in intervertebral disc degeneration
por: Song, Yu, et al.
Publicado: (2021)

The Role of Oxidative Stress in Intervertebral Disc Degeneration
por: Cao, Guoshuai, et al.
Publicado: (2022)

Targeting ATM to mitigate intervertebral disc degeneration
por: Pitcher, Louise E., et al.
Publicado: (2021)

Editorial: Biomaterial advances in intervertebral disc degeneration
por: Huang, Yong, et al.
Publicado: (2023)

Disordered Mechanical Stress and Tissue Engineering Therapies in Intervertebral Disc Degeneration
por: Zhao, Runze, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ahqdt495sl210ohbbavmbirn9g