Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice

OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly coexist and act synergistically to drive adverse clinical outcomes. This study is aimed at investigating the effects of exercise intervention and oral hypoglycaemic drug of metformin (MET) alone or combined on he...

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Detalles Bibliográficos
Autores principales: Zhang, Yuan, Liu, Yuting, Liu, Xiaowei, Yuan, Xinmeng, Xiang, Mengqi, Liu, Jingjing, Zhang, Liumei, Zhu, Shouqian, Lu, Jiao, Tang, Qiang, Cheng, Sulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481363/
https://www.ncbi.nlm.nih.gov/pubmed/36120597
http://dx.doi.org/10.1155/2022/2297268

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