WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome

Werner Syndrome (WS) is an autosomal recessive disorder characterized by premature aging due to mutations of the WRN gene. A classical sign in WS patients is short stature, but the underlying mechanisms are not well understood. Here we report that WRN is indispensable for chondrogenesis, which is th...

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Detalles Bibliográficos
Autores principales: Tian, Yuyao, Wang, Wuming, Lautrup, Sofie, Zhao, Hui, Li, Xiang, Law, Patrick Wai Nok, Dinh, Ngoc-Duy, Fang, Evandro Fei, Cheung, Hoi Hung, Chan, Wai-Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481537/
https://www.ncbi.nlm.nih.gov/pubmed/36114168
http://dx.doi.org/10.1038/s41467-022-33012-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481537/
https://www.ncbi.nlm.nih.gov/pubmed/36114168
http://dx.doi.org/10.1038/s41467-022-33012-6

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