A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II

Survival of motor neuron (SMN) functions in diverse biological pathways via recognition of symmetric dimethylarginine (Rme2s) on proteins by its Tudor domain, and deficiency of SMN leads to spinal muscular atrophy. Here we report a potent and selective antagonist with a 4-iminopyridine scaffold targ...

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Detalles Bibliográficos
Autores principales: Liu, Yanli, Iqbal, Aman, Li, Weiguo, Ni, Zuyao, Wang, Yalong, Ramprasad, Jurupula, Abraham, Karan Joshua, Zhang, Mengmeng, Zhao, Dorothy Yanling, Qin, Su, Loppnau, Peter, Jiang, Honglv, Guo, Xinghua, Brown, Peter J., Zhen, Xuechu, Xu, Guoqiang, Mekhail, Karim, Ji, Xingyue, Bedford, Mark T., Greenblatt, Jack F., Min, Jinrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481570/
https://www.ncbi.nlm.nih.gov/pubmed/36114190
http://dx.doi.org/10.1038/s41467-022-33229-5

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