MicroRNA-570 targets the HSP chaperone network, increases proteotoxic stress and inhibits mammary tumor cell migration

The dynamic network of chaperone interactions known as the chaperome contributes significantly to the proteotoxic cell response and the malignant phenotype. To bypass the inherent redundancy in the network, we have used a microRNA (mir) approach to target multiple members of the chaperome simultaneo...

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Detalles Bibliográficos
Autores principales: Okusha, Yuka, Guerrero-Gimenez, Martin E., Lang, Benjamin J., Borges, Thiago J., Stevenson, Mary A., Truman, Andrew W., Calderwood, Stuart K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481609/
https://www.ncbi.nlm.nih.gov/pubmed/36114410
http://dx.doi.org/10.1038/s41598-022-19533-6

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