Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer

Mutations in the TERT promoter represent the genetic underpinnings of tumor cell immortality. Beyond the two most common point mutations, which selectively recruit the ETS factor GABP to activate TERT, the significance of other variants is unknown. In seven cancer types, we identify duplications of...

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Detalles Bibliográficos
Autores principales: Barger, Carter J., Suwala, Abigail K., Soczek, Katarzyna M., Wang, Albert S., Kim, Min Y., Hong, Chibo, Doudna, Jennifer A., Chang, Susan M., Phillips, Joanna J., Solomon, David A., Costello, Joseph F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481613/
https://www.ncbi.nlm.nih.gov/pubmed/36114166
http://dx.doi.org/10.1038/s41467-022-33099-x

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