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Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

α-Synuclein (αSyn) aggregation in Lewy bodies and neurites defines both familial and ‘sporadic’ Parkinson’s disease. We previously identified α-helically folded αSyn tetramers, in addition to the long-known unfolded monomers, in normal cells. PD-causing αSyn mutations decrease the tetramer:monomer (...

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Detalles Bibliográficos
Autores principales:	Fonseca-Ornelas, Luis, Stricker, Jonathan M. S., Soriano-Cruz, Stephanie, Weykopf, Beatrice, Dettmer, Ulf, Muratore, Christina R., Scherzer, Clemens R., Selkoe, Dennis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481630/ https://www.ncbi.nlm.nih.gov/pubmed/36114228 http://dx.doi.org/10.1038/s41531-022-00380-1

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