Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

Topoisomerase I (TOP1) controls the topological state of DNA during DNA replication, and its dysfunction due to treatment with an inhibitor, such as camptothecin (CPT), causes replication arrest and cell death. Although CPT has excellent cytotoxicity, it has the disadvantage of instability under phy...

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Detalles Bibliográficos
Autores principales: Nishida, Masahiro, Terabayashi, Takeshi, Matsuoka, Shigeru, Okuma, Tomoko, Adachi, Sawako, Tomo, Tadashi, Kawano, Masanori, Tanaka, Kazuhiro, Tsumura, Hiroshi, Anai, Hirofumi, Ishizaki, Toshimasa, Nishida, Yoshihiro, Hanada, Katsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481636/
https://www.ncbi.nlm.nih.gov/pubmed/36114357
http://dx.doi.org/10.1038/s42003-022-03920-w

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