Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia

TREM2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for Alzheimer’s disease (AD). As microglial responses modulated by TREM2 are central to AD pathogenesis, enhancing TREM2 signaling has been explored as an AD therapeutic strategy. However, the effective thera...

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Detalles Bibliográficos
Autores principales: Zhao, Na, Qiao, Wenhui, Li, Fuyao, Ren, Yingxue, Zheng, Jiaying, Martens, Yuka A., Wang, Xusheng, Li, Ling, Liu, Chia-Chen, Chen, Kai, Zhu, Yiyang, Ikezu, Tadafumi C., Li, Zonghua, Meneses, Axel D., Jin, Yunjung, Knight, Joshua A., Chen, Yixing, Bastea, Ligia, Linares, Cynthia, Sonustun, Berkiye, Job, Lucy, Smith, Madeleine L., Xie, Manling, Liu, Yong U., Umpierre, Anthony D., Haruwaka, Koichiro, Quicksall, Zachary S., Storz, Peter, Asmann, Yan W., Wu, Long-Jun, Bu, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481739/
https://www.ncbi.nlm.nih.gov/pubmed/36107206
http://dx.doi.org/10.1084/jem.20212479

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