Cargando…
Chronic nonbacterial osteomyelitis: the role of whole-body MRI
BACKGROUND: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a noninfectious autoinflammatory disorder that occurs primarily in children and adolescents and is characterized by episodic musculoskeletal pain with a protracted course. MAIN BODY: Tr...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481810/ https://www.ncbi.nlm.nih.gov/pubmed/36114435 http://dx.doi.org/10.1186/s13244-022-01288-3 |
_version_ | 1784791328106741760 |
---|---|
author | Nico, Marcelo Astolfi Caetano Araújo, Flávia Ferreira Guimarães, Júlio Brandão da Cruz, Isabela Azevedo Nicodemos Silva, Flávio Duarte Carneiro, Bruno Cerretti Filho, Alípio Gomes Ormond |
author_facet | Nico, Marcelo Astolfi Caetano Araújo, Flávia Ferreira Guimarães, Júlio Brandão da Cruz, Isabela Azevedo Nicodemos Silva, Flávio Duarte Carneiro, Bruno Cerretti Filho, Alípio Gomes Ormond |
author_sort | Nico, Marcelo Astolfi Caetano |
collection | PubMed |
description | BACKGROUND: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a noninfectious autoinflammatory disorder that occurs primarily in children and adolescents and is characterized by episodic musculoskeletal pain with a protracted course. MAIN BODY: Traditionally, the diagnosis of CNO is made by exclusion and commonly requires bone biopsy to rule out infection and malignancy. However, bone biopsy may be avoided when imaging and clinical characteristic features are present, such as multifocal bone lesions at typical sites, no constitutional symptoms and no signs of infection in laboratory test results. Whole-body magnetic resonance imaging (WB-MRI) can assess signs of acute and chronic inflammation and enables the detection of CNO typical patterns of lesion location and distribution, thereby helping to exclude differential diagnosis. The goal of the present study paper is to review the main clinical and imaging aspects of the disease with emphasis on the role of WB-MRI in the diagnosis, assessment of disease burden and follow-up monitoring. CONCLUSION: Radiologists need to be familiar with the imaging features to suggest the diagnosis as the early therapy may help to avoid irreversible secondary damage of skeletal system. |
format | Online Article Text |
id | pubmed-9481810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-94818102022-10-20 Chronic nonbacterial osteomyelitis: the role of whole-body MRI Nico, Marcelo Astolfi Caetano Araújo, Flávia Ferreira Guimarães, Júlio Brandão da Cruz, Isabela Azevedo Nicodemos Silva, Flávio Duarte Carneiro, Bruno Cerretti Filho, Alípio Gomes Ormond Insights Imaging Educational Review BACKGROUND: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a noninfectious autoinflammatory disorder that occurs primarily in children and adolescents and is characterized by episodic musculoskeletal pain with a protracted course. MAIN BODY: Traditionally, the diagnosis of CNO is made by exclusion and commonly requires bone biopsy to rule out infection and malignancy. However, bone biopsy may be avoided when imaging and clinical characteristic features are present, such as multifocal bone lesions at typical sites, no constitutional symptoms and no signs of infection in laboratory test results. Whole-body magnetic resonance imaging (WB-MRI) can assess signs of acute and chronic inflammation and enables the detection of CNO typical patterns of lesion location and distribution, thereby helping to exclude differential diagnosis. The goal of the present study paper is to review the main clinical and imaging aspects of the disease with emphasis on the role of WB-MRI in the diagnosis, assessment of disease burden and follow-up monitoring. CONCLUSION: Radiologists need to be familiar with the imaging features to suggest the diagnosis as the early therapy may help to avoid irreversible secondary damage of skeletal system. Springer Vienna 2022-09-16 /pmc/articles/PMC9481810/ /pubmed/36114435 http://dx.doi.org/10.1186/s13244-022-01288-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Educational Review Nico, Marcelo Astolfi Caetano Araújo, Flávia Ferreira Guimarães, Júlio Brandão da Cruz, Isabela Azevedo Nicodemos Silva, Flávio Duarte Carneiro, Bruno Cerretti Filho, Alípio Gomes Ormond Chronic nonbacterial osteomyelitis: the role of whole-body MRI |
title | Chronic nonbacterial osteomyelitis: the role of whole-body MRI |
title_full | Chronic nonbacterial osteomyelitis: the role of whole-body MRI |
title_fullStr | Chronic nonbacterial osteomyelitis: the role of whole-body MRI |
title_full_unstemmed | Chronic nonbacterial osteomyelitis: the role of whole-body MRI |
title_short | Chronic nonbacterial osteomyelitis: the role of whole-body MRI |
title_sort | chronic nonbacterial osteomyelitis: the role of whole-body mri |
topic | Educational Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481810/ https://www.ncbi.nlm.nih.gov/pubmed/36114435 http://dx.doi.org/10.1186/s13244-022-01288-3 |
work_keys_str_mv | AT nicomarceloastolficaetano chronicnonbacterialosteomyelitistheroleofwholebodymri AT araujoflaviaferreira chronicnonbacterialosteomyelitistheroleofwholebodymri AT guimaraesjuliobrandao chronicnonbacterialosteomyelitistheroleofwholebodymri AT dacruzisabelaazevedonicodemos chronicnonbacterialosteomyelitistheroleofwholebodymri AT silvaflavioduarte chronicnonbacterialosteomyelitistheroleofwholebodymri AT carneirobrunocerretti chronicnonbacterialosteomyelitistheroleofwholebodymri AT filhoalipiogomesormond chronicnonbacterialosteomyelitistheroleofwholebodymri |