Cargando…

Chronic nonbacterial osteomyelitis: the role of whole-body MRI

BACKGROUND: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a noninfectious autoinflammatory disorder that occurs primarily in children and adolescents and is characterized by episodic musculoskeletal pain with a protracted course. MAIN BODY: Tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Nico, Marcelo Astolfi Caetano, Araújo, Flávia Ferreira, Guimarães, Júlio Brandão, da Cruz, Isabela Azevedo Nicodemos, Silva, Flávio Duarte, Carneiro, Bruno Cerretti, Filho, Alípio Gomes Ormond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481810/
https://www.ncbi.nlm.nih.gov/pubmed/36114435
http://dx.doi.org/10.1186/s13244-022-01288-3
_version_ 1784791328106741760
author Nico, Marcelo Astolfi Caetano
Araújo, Flávia Ferreira
Guimarães, Júlio Brandão
da Cruz, Isabela Azevedo Nicodemos
Silva, Flávio Duarte
Carneiro, Bruno Cerretti
Filho, Alípio Gomes Ormond
author_facet Nico, Marcelo Astolfi Caetano
Araújo, Flávia Ferreira
Guimarães, Júlio Brandão
da Cruz, Isabela Azevedo Nicodemos
Silva, Flávio Duarte
Carneiro, Bruno Cerretti
Filho, Alípio Gomes Ormond
author_sort Nico, Marcelo Astolfi Caetano
collection PubMed
description BACKGROUND: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a noninfectious autoinflammatory disorder that occurs primarily in children and adolescents and is characterized by episodic musculoskeletal pain with a protracted course. MAIN BODY: Traditionally, the diagnosis of CNO is made by exclusion and commonly requires bone biopsy to rule out infection and malignancy. However, bone biopsy may be avoided when imaging and clinical characteristic features are present, such as multifocal bone lesions at typical sites, no constitutional symptoms and no signs of infection in laboratory test results. Whole-body magnetic resonance imaging (WB-MRI) can assess signs of acute and chronic inflammation and enables the detection of CNO typical patterns of lesion location and distribution, thereby helping to exclude differential diagnosis. The goal of the present study paper is to review the main clinical and imaging aspects of the disease with emphasis on the role of WB-MRI in the diagnosis, assessment of disease burden and follow-up monitoring. CONCLUSION: Radiologists need to be familiar with the imaging features to suggest the diagnosis as the early therapy may help to avoid irreversible secondary damage of skeletal system.
format Online
Article
Text
id pubmed-9481810
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-94818102022-10-20 Chronic nonbacterial osteomyelitis: the role of whole-body MRI Nico, Marcelo Astolfi Caetano Araújo, Flávia Ferreira Guimarães, Júlio Brandão da Cruz, Isabela Azevedo Nicodemos Silva, Flávio Duarte Carneiro, Bruno Cerretti Filho, Alípio Gomes Ormond Insights Imaging Educational Review BACKGROUND: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a noninfectious autoinflammatory disorder that occurs primarily in children and adolescents and is characterized by episodic musculoskeletal pain with a protracted course. MAIN BODY: Traditionally, the diagnosis of CNO is made by exclusion and commonly requires bone biopsy to rule out infection and malignancy. However, bone biopsy may be avoided when imaging and clinical characteristic features are present, such as multifocal bone lesions at typical sites, no constitutional symptoms and no signs of infection in laboratory test results. Whole-body magnetic resonance imaging (WB-MRI) can assess signs of acute and chronic inflammation and enables the detection of CNO typical patterns of lesion location and distribution, thereby helping to exclude differential diagnosis. The goal of the present study paper is to review the main clinical and imaging aspects of the disease with emphasis on the role of WB-MRI in the diagnosis, assessment of disease burden and follow-up monitoring. CONCLUSION: Radiologists need to be familiar with the imaging features to suggest the diagnosis as the early therapy may help to avoid irreversible secondary damage of skeletal system. Springer Vienna 2022-09-16 /pmc/articles/PMC9481810/ /pubmed/36114435 http://dx.doi.org/10.1186/s13244-022-01288-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Educational Review
Nico, Marcelo Astolfi Caetano
Araújo, Flávia Ferreira
Guimarães, Júlio Brandão
da Cruz, Isabela Azevedo Nicodemos
Silva, Flávio Duarte
Carneiro, Bruno Cerretti
Filho, Alípio Gomes Ormond
Chronic nonbacterial osteomyelitis: the role of whole-body MRI
title Chronic nonbacterial osteomyelitis: the role of whole-body MRI
title_full Chronic nonbacterial osteomyelitis: the role of whole-body MRI
title_fullStr Chronic nonbacterial osteomyelitis: the role of whole-body MRI
title_full_unstemmed Chronic nonbacterial osteomyelitis: the role of whole-body MRI
title_short Chronic nonbacterial osteomyelitis: the role of whole-body MRI
title_sort chronic nonbacterial osteomyelitis: the role of whole-body mri
topic Educational Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481810/
https://www.ncbi.nlm.nih.gov/pubmed/36114435
http://dx.doi.org/10.1186/s13244-022-01288-3
work_keys_str_mv AT nicomarceloastolficaetano chronicnonbacterialosteomyelitistheroleofwholebodymri
AT araujoflaviaferreira chronicnonbacterialosteomyelitistheroleofwholebodymri
AT guimaraesjuliobrandao chronicnonbacterialosteomyelitistheroleofwholebodymri
AT dacruzisabelaazevedonicodemos chronicnonbacterialosteomyelitistheroleofwholebodymri
AT silvaflavioduarte chronicnonbacterialosteomyelitistheroleofwholebodymri
AT carneirobrunocerretti chronicnonbacterialosteomyelitistheroleofwholebodymri
AT filhoalipiogomesormond chronicnonbacterialosteomyelitistheroleofwholebodymri