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MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results

OBJECTIVES: To evaluate the therapeutic effect of neoadjuvant therapy (NAT) followed by radical hysterectomy and concurrent chemoradiotherapy (CCRT) in stage IB2 and IIA2 squamous cervical cancer (SCC) and investigate the value of apparent diffusion coefficient (ADC) in outcome evaluation of differe...

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Autores principales: Song, Qingling, Pang, Huiting, Tong, Rui, Zhu, Yanmei, Luo, Yahong, Yu, Tao, Liu, Fan, Dong, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481843/
https://www.ncbi.nlm.nih.gov/pubmed/36114356
http://dx.doi.org/10.1186/s13244-022-01269-6
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author Song, Qingling
Pang, Huiting
Tong, Rui
Zhu, Yanmei
Luo, Yahong
Yu, Tao
Liu, Fan
Dong, Yue
author_facet Song, Qingling
Pang, Huiting
Tong, Rui
Zhu, Yanmei
Luo, Yahong
Yu, Tao
Liu, Fan
Dong, Yue
author_sort Song, Qingling
collection PubMed
description OBJECTIVES: To evaluate the therapeutic effect of neoadjuvant therapy (NAT) followed by radical hysterectomy and concurrent chemoradiotherapy (CCRT) in stage IB2 and IIA2 squamous cervical cancer (SCC) and investigate the value of apparent diffusion coefficient (ADC) in outcome evaluation of different treatment strategies in the patients. METHODS: A total of 149 patients with IB2 and IIA2 SCC who underwent pretreatment MRI and DWI scan were included. Patients were treated with NAT + RH or CCRT. Clinical indices and pathological factors were recorded. The imaging indices were measured including tumor size and tumor ADC values. Intraclass correlation coefficient was employed to evaluate the consistency of the indices measured by two observers. ROC curves were used to evaluate the cutoff values of clinical and imaging indices. Kaplan–Meier and Cox proportional hazard model were used to analyze the independent factors of disease-free survival (DFS). RESULTS: The median follow-up period was 42.3 months. SCC-Ag, ADCmax and ADCmin were independent factors for DFS in the entire cohort. SCC-Ag, ADCmin and vascular invasion were independent factors for DFS in NAT + RH group. ADCmax and ADCmin were independent factors for DFS in CCRT group. ADCmin was the strongest independent factor for DFS in NAT + RH group, while ADCmax was that in CCRT group. CONCLUSION: The NAT + RH patients had similar DFS to that of CCRT in IB2 and IIA2 SCC, which could be a potential feasible alternative treatment. ADCmin and ADCmax were more valuable in evaluating the outcome of patients who underwent NAT + RH or CCRT, respectively.
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spelling pubmed-94818432022-10-20 MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results Song, Qingling Pang, Huiting Tong, Rui Zhu, Yanmei Luo, Yahong Yu, Tao Liu, Fan Dong, Yue Insights Imaging Original Article OBJECTIVES: To evaluate the therapeutic effect of neoadjuvant therapy (NAT) followed by radical hysterectomy and concurrent chemoradiotherapy (CCRT) in stage IB2 and IIA2 squamous cervical cancer (SCC) and investigate the value of apparent diffusion coefficient (ADC) in outcome evaluation of different treatment strategies in the patients. METHODS: A total of 149 patients with IB2 and IIA2 SCC who underwent pretreatment MRI and DWI scan were included. Patients were treated with NAT + RH or CCRT. Clinical indices and pathological factors were recorded. The imaging indices were measured including tumor size and tumor ADC values. Intraclass correlation coefficient was employed to evaluate the consistency of the indices measured by two observers. ROC curves were used to evaluate the cutoff values of clinical and imaging indices. Kaplan–Meier and Cox proportional hazard model were used to analyze the independent factors of disease-free survival (DFS). RESULTS: The median follow-up period was 42.3 months. SCC-Ag, ADCmax and ADCmin were independent factors for DFS in the entire cohort. SCC-Ag, ADCmin and vascular invasion were independent factors for DFS in NAT + RH group. ADCmax and ADCmin were independent factors for DFS in CCRT group. ADCmin was the strongest independent factor for DFS in NAT + RH group, while ADCmax was that in CCRT group. CONCLUSION: The NAT + RH patients had similar DFS to that of CCRT in IB2 and IIA2 SCC, which could be a potential feasible alternative treatment. ADCmin and ADCmax were more valuable in evaluating the outcome of patients who underwent NAT + RH or CCRT, respectively. Springer Vienna 2022-09-16 /pmc/articles/PMC9481843/ /pubmed/36114356 http://dx.doi.org/10.1186/s13244-022-01269-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Song, Qingling
Pang, Huiting
Tong, Rui
Zhu, Yanmei
Luo, Yahong
Yu, Tao
Liu, Fan
Dong, Yue
MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results
title MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results
title_full MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results
title_fullStr MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results
title_full_unstemmed MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results
title_short MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results
title_sort mri outcome evaluation in patients with ib2 and iia2 squamous cervical cancer stages: preliminary results
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481843/
https://www.ncbi.nlm.nih.gov/pubmed/36114356
http://dx.doi.org/10.1186/s13244-022-01269-6
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