Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of T(SCM)-enriched allogeneic CAR-T cells

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The use of T cells from healthy donors for allogeneic chimeric antigen receptor T (CAR-T) cell cancer therapy is attractive because healthy donor T cells can produce versatile off-the-shelf CAR-T treatments. To maximize safety and durability of allogeneic products, the endogenous T cell receptor and...

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Detalles Bibliográficos
Autores principales: Madison, Blair B., Patil, Deepak, Richter, Maximilian, Li, Xianghong, Tong, Min, Cranert, Stacey, Wang, Xinxin, Martin, Renata, Xi, Haibin, Tan, Yening, Weiss, Leslie, Marquez, Karl, Coronella, Julia, Shedlock, Devon J., Ostertag, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481872/
https://www.ncbi.nlm.nih.gov/pubmed/36189080
http://dx.doi.org/10.1016/j.omtn.2022.06.003
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