Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes

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Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide great opportunities for mechanistic dissection of human cardiac pathophysiology; however, hiPSC-CMs remain immature relative to the adult heart. To identify novel signaling pathways driving the maturation process during h...

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Detalles Bibliográficos
Autores principales: Garay, Bayardo I., Givens, Sophie, Abreu, Phablo, Liu, Man, Yücel, Doğacan, Baik, June, Stanis, Noah, Rothermel, Taylor M., Magli, Alessandro, Abrahante, Juan E., Goloviznina, Natalya A., Soliman, Hossam A.N., Dhoke, Neha R., Kyba, Michael, Alford, Patrick W., Dudley, Samuel C., van Berlo, Jop H., Ogle, Brenda, Perlingeiro, Rita R.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481895/
https://www.ncbi.nlm.nih.gov/pubmed/35931076
http://dx.doi.org/10.1016/j.stemcr.2022.07.003
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