The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling

IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown. Here, we describe that IL-6 is necessary for C/EBPα-enhanced reprogramming of...

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Detalles Bibliográficos
Autores principales: Plana-Carmona, Marcos, Stik, Gregoire, Bulteau, Romain, Segura-Morales, Carolina, Alcázar, Noelia, Wyatt, Chris D.R., Klonizakis, Antonios, de Andrés-Aguayo, Luisa, Gasnier, Maxime, Tian, Tian V., Torcal Garcia, Guillem, Vila-Casadesús, Maria, Plachta, Nicolas, Serrano, Manuel, Francesconi, Mirko, Graf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481899/
https://www.ncbi.nlm.nih.gov/pubmed/35961310
http://dx.doi.org/10.1016/j.stemcr.2022.07.009

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