Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol

Mutations in the MAPT gene that encodes tau lead to frontotemporal dementia (FTD) with pathology evident in both cerebral neurons and glia. Human cerebral organoids (hCOs) from individuals harboring pathogenic tau mutations can reveal the earliest downstream effects on molecular pathways within a de...

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Detalles Bibliográficos
Autores principales: Glasauer, Stella M.K., Goderie, Susan K., Rauch, Jennifer N., Guzman, Elmer, Audouard, Morgane, Bertucci, Taylor, Joy, Shona, Rommelfanger, Emma, Luna, Gabriel, Keane-Rivera, Erica, Lotz, Steven, Borden, Susan, Armando, Aaron M., Quehenberger, Oswald, Temple, Sally, Kosik, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481908/
https://www.ncbi.nlm.nih.gov/pubmed/35985329
http://dx.doi.org/10.1016/j.stemcr.2022.07.011

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