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The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis

Mutations in the embryonic ectoderm development (EED) cause Weaver syndrome, but whether and how EED affects embryonic brain development remains elusive. Here, we generated a mouse model in which Eed was deleted in the forebrain to investigate the role of EED. We found that deletion of Eed decreased...

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Detalles Bibliográficos
Autores principales:	Zhang, Shuang-Feng, Dai, Shang-Kun, Du, Hong-Zhen, Wang, Hui, Li, Xing-Guo, Tang, Yi, Liu, Chang-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481917/ https://www.ncbi.nlm.nih.gov/pubmed/35931079 http://dx.doi.org/10.1016/j.stemcr.2022.07.004

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