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Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets

Human embryonic stem cells (hESCs) provide opportunities for cell replacement therapy of insulin-dependent diabetes. Therapeutic quantities of human stem cell-derived islets (SC-islets) can be produced by directed differentiation. However, preventing allo-rejection and recurring autoimmunity, withou...

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Detalles Bibliográficos
Autores principales:	Sintov, Elad, Nikolskiy, Igor, Barrera, Victor, Hyoje-Ryu Kenty, Jennifer, Atkin, Alexander S., Gerace, Dario, Ho Sui, Shannan J., Boulanger, Kyle, Melton, Douglas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481918/ https://www.ncbi.nlm.nih.gov/pubmed/36055241 http://dx.doi.org/10.1016/j.stemcr.2022.08.002

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