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Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons

Disruption of endolysosomal and autophagy-lysosomal systems is increasingly implicated in neurodegeneration. Sodium-proton exchanger 6 (NHE6) contributes to the maintenance of proper endosomal pH, and loss-of function mutations in the X-linked NHE6 lead to Christianson syndrome (CS) in males. Neurod...

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Detalles Bibliográficos
Autores principales:	Fernandez, Marty A., Bah, Fatmata, Ma, Li, Lee, YouJin, Schmidt, Michael, Welch, Elizabeth, Morrow, Eric M., Young-Pearse, Tracy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481919/ https://www.ncbi.nlm.nih.gov/pubmed/36055242 http://dx.doi.org/10.1016/j.stemcr.2022.08.001

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