Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition

Although circadian and sleep disorders are frequently associated with autism spectrum disorders (ASD), it remains elusive whether clock gene disruption can lead to autistic-like phenotypes in animals. The essential clock gene Bmal1 has been associated with human sociability and its missense mutation...

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Detalles Bibliográficos
Autores principales: Liu, Dong, Nanclares, Carmen, Simbriger, Konstanze, Fang, Kun, Lorsung, Ethan, Le, Nam, Amorim, Inês Silva, Chalkiadaki, Kleanthi, Pathak, Salil Saurav, Li, Jin, Gewirtz, Jonathan C., Jin, Victor X., Kofuji, Paulo, Araque, Alfonso, Orr, Harry T., Gkogkas, Christos G., Cao, Ruifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481983/
https://www.ncbi.nlm.nih.gov/pubmed/35301425
http://dx.doi.org/10.1038/s41380-022-01499-6

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