Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo

Persistence of chronic hepatitis B (CHB) is attributed to maintenance of the intrahepatic pool of the viral covalently closed circular DNA (cccDNA), which serves as the transcriptional template for all viral gene products required for replication. Current nucleos(t)ide therapies for CHB prevent viru...

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Detalles Bibliográficos
Autores principales: Gorsuch, Cassandra L., Nemec, Paige, Yu, Mei, Xu, Simin, Han, Dong, Smith, Jeff, Lape, Janel, van Buuren, Nicholas, Ramirez, Ricardo, Muench, Robert C., Holdorf, Meghan M., Feierbach, Becket, Falls, Greg, Holt, Jason, Shoop, Wendy, Sevigny, Emma, Karriker, Forrest, Brown, Robert V., Joshi, Amod, Goodwin, Tyler, Tam, Ying K., Lin, Paulo J.C., Semple, Sean C., Leatherbury, Neil, Delaney IV, William E., Jantz, Derek, Rhoden Smith, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9481990/
https://www.ncbi.nlm.nih.gov/pubmed/35581938
http://dx.doi.org/10.1016/j.ymthe.2022.05.013

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