A review on the role of MEG8 lncRNA in human disorders

Maternally expressed 8 (MEG8) is a long non-coding RNA which is expressed in the nucleus. It is highly expressed in adrenal, placenta and brain. Recent studies have shown contribution of MEG8 in different disorders ranging from neoplastic ones to diabetic nephropathy, atherosclerosis, ischemic strok...

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Autores principales: Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Hussen, Bashdar Mahmud, Taheri, Mohammad, Shojaei, Seyedpouzhia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482158/
https://www.ncbi.nlm.nih.gov/pubmed/36114498
http://dx.doi.org/10.1186/s12935-022-02705-9
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author Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Shojaei, Seyedpouzhia
author_facet Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Shojaei, Seyedpouzhia
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Maternally expressed 8 (MEG8) is a long non-coding RNA which is expressed in the nucleus. It is highly expressed in adrenal, placenta and brain. Recent studies have shown contribution of MEG8 in different disorders ranging from neoplastic ones to diabetic nephropathy, atherosclerosis, ischemic stroke, trophoblast dysfunction and abortion, Henoch-Schonlein purpura and osteoarthritis. It has an oncogenic role in the development of lung, pancreatic and liver cancer. In the current review, we summarize the role of this lncRNA in mentioned disorders, based on the evidence obtained from in vitro, in vivo and human studies.
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spelling pubmed-94821582022-09-18 A review on the role of MEG8 lncRNA in human disorders Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Taheri, Mohammad Shojaei, Seyedpouzhia Cancer Cell Int Review Maternally expressed 8 (MEG8) is a long non-coding RNA which is expressed in the nucleus. It is highly expressed in adrenal, placenta and brain. Recent studies have shown contribution of MEG8 in different disorders ranging from neoplastic ones to diabetic nephropathy, atherosclerosis, ischemic stroke, trophoblast dysfunction and abortion, Henoch-Schonlein purpura and osteoarthritis. It has an oncogenic role in the development of lung, pancreatic and liver cancer. In the current review, we summarize the role of this lncRNA in mentioned disorders, based on the evidence obtained from in vitro, in vivo and human studies. BioMed Central 2022-09-16 /pmc/articles/PMC9482158/ /pubmed/36114498 http://dx.doi.org/10.1186/s12935-022-02705-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Shojaei, Seyedpouzhia
A review on the role of MEG8 lncRNA in human disorders
title A review on the role of MEG8 lncRNA in human disorders
title_full A review on the role of MEG8 lncRNA in human disorders
title_fullStr A review on the role of MEG8 lncRNA in human disorders
title_full_unstemmed A review on the role of MEG8 lncRNA in human disorders
title_short A review on the role of MEG8 lncRNA in human disorders
title_sort review on the role of meg8 lncrna in human disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482158/
https://www.ncbi.nlm.nih.gov/pubmed/36114498
http://dx.doi.org/10.1186/s12935-022-02705-9
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