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The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality
BACKGROUND: Current evidence demonstrates that blood glucose fluctuation can be associated with depression and anxiety. The association among blood glucose fluctuation, traditional risk factors and emotional disorders in T2DM should be studied and clarified. METHODS: A total of 182 diabetic patients...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482159/ https://www.ncbi.nlm.nih.gov/pubmed/36114534 http://dx.doi.org/10.1186/s12902-022-01147-8 |
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author | Yang, Wei Liu, Min Tian, Yuan Zhang, Qianwei Zhang, Jiahua Chen, Qiaoyun Suo, Lixia Chen, Yang |
author_facet | Yang, Wei Liu, Min Tian, Yuan Zhang, Qianwei Zhang, Jiahua Chen, Qiaoyun Suo, Lixia Chen, Yang |
author_sort | Yang, Wei |
collection | PubMed |
description | BACKGROUND: Current evidence demonstrates that blood glucose fluctuation can be associated with depression and anxiety. The association among blood glucose fluctuation, traditional risk factors and emotional disorders in T2DM should be studied and clarified. METHODS: A total of 182 diabetic patients including 81 patients with depression or anxiety and 101 patients without emotional disorder were enrolled into this study. Data were obtained through medical history and questionnaire survey. Data were analyzed using appropriate statistical methods. RESULTS: The comparison results of basic information between the two groups showed that the differences of the proportion of female were statistically significant (p = 0.002). There was no statistical difference in laboratory examination indexes between the two groups, however, standard deviation of blood glucose (SDBG) and postprandial glucose excursion (PPGE) of the comorbidity group were significantly higher than that of control group (p = 0.032 and p = 0.037). The results of questionnaire survey showed that there were statistically significant differences in sleep quality, PSQI and dietary habit between the two groups (p < 0.001, p < 0.001 and p < 0.001). Stratified analysis results according to gender showed that the percentage of cognitive disorder, anxiety and depression in female group was significantly higher than that in male group (p = 0.001, p < 0.001 and p < 0.001). Mini-mental state examination (MMSE), self-rating anxiety scale (SAS) and patient health questionnaire (PHQ-9) score in female group were also higher than male group (p = 0.001, p < 0.001 and p < 0.001). Logistic regression analysis results showed that SDBG and sleep quality were associated with emotional disorders in T2DM (p = 0.040 and p < 0.001) and the OR values of these factors were 7.588 (1.097–52.069) and 4.428 (2.649–7.401). CONCLUSIONS: Blood glucose fluctuation and sleep quality are associated with the increased prevalence of depression and anxiety disorders in T2DM. |
format | Online Article Text |
id | pubmed-9482159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94821592022-09-18 The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality Yang, Wei Liu, Min Tian, Yuan Zhang, Qianwei Zhang, Jiahua Chen, Qiaoyun Suo, Lixia Chen, Yang BMC Endocr Disord Research BACKGROUND: Current evidence demonstrates that blood glucose fluctuation can be associated with depression and anxiety. The association among blood glucose fluctuation, traditional risk factors and emotional disorders in T2DM should be studied and clarified. METHODS: A total of 182 diabetic patients including 81 patients with depression or anxiety and 101 patients without emotional disorder were enrolled into this study. Data were obtained through medical history and questionnaire survey. Data were analyzed using appropriate statistical methods. RESULTS: The comparison results of basic information between the two groups showed that the differences of the proportion of female were statistically significant (p = 0.002). There was no statistical difference in laboratory examination indexes between the two groups, however, standard deviation of blood glucose (SDBG) and postprandial glucose excursion (PPGE) of the comorbidity group were significantly higher than that of control group (p = 0.032 and p = 0.037). The results of questionnaire survey showed that there were statistically significant differences in sleep quality, PSQI and dietary habit between the two groups (p < 0.001, p < 0.001 and p < 0.001). Stratified analysis results according to gender showed that the percentage of cognitive disorder, anxiety and depression in female group was significantly higher than that in male group (p = 0.001, p < 0.001 and p < 0.001). Mini-mental state examination (MMSE), self-rating anxiety scale (SAS) and patient health questionnaire (PHQ-9) score in female group were also higher than male group (p = 0.001, p < 0.001 and p < 0.001). Logistic regression analysis results showed that SDBG and sleep quality were associated with emotional disorders in T2DM (p = 0.040 and p < 0.001) and the OR values of these factors were 7.588 (1.097–52.069) and 4.428 (2.649–7.401). CONCLUSIONS: Blood glucose fluctuation and sleep quality are associated with the increased prevalence of depression and anxiety disorders in T2DM. BioMed Central 2022-09-17 /pmc/articles/PMC9482159/ /pubmed/36114534 http://dx.doi.org/10.1186/s12902-022-01147-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yang, Wei Liu, Min Tian, Yuan Zhang, Qianwei Zhang, Jiahua Chen, Qiaoyun Suo, Lixia Chen, Yang The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality |
title | The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality |
title_full | The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality |
title_fullStr | The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality |
title_full_unstemmed | The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality |
title_short | The increased prevalence of depression and anxiety in T2DM patients associated with blood glucose fluctuation and sleep quality |
title_sort | increased prevalence of depression and anxiety in t2dm patients associated with blood glucose fluctuation and sleep quality |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482159/ https://www.ncbi.nlm.nih.gov/pubmed/36114534 http://dx.doi.org/10.1186/s12902-022-01147-8 |
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