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A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancer

BACKGROUND: Previous assessments of peritumoral inflammatory infiltrate in colorectal cancer (CRC) have focused on the role of CD8(+) T lymphocytes. We sought to compare the prognostic value of CD8 with downstream indicators of active immune cell function, specifically granzyme B (GZMB) and CD68 in...

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Detalles Bibliográficos
Autores principales:	Noti, Luca, Galván, José A., Dawson, Heather, Lugli, Alessandro, Kirsch, Richard, Assarzadegan, Naziheh, Messenger, David, Krebs, Philippe, Berger, Martin D., Zlobec, Inti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482175/ https://www.ncbi.nlm.nih.gov/pubmed/36114487 http://dx.doi.org/10.1186/s12885-022-10048-x

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