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Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer’s di...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482276/ https://www.ncbi.nlm.nih.gov/pubmed/36115967 http://dx.doi.org/10.1186/s13195-022-01077-6 |
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author | Arighi, Andrea Arcaro, Marina Fumagalli, Giorgio Giulio Carandini, Tiziana Pietroboni, Anna Margherita Sacchi, Luca Fenoglio, Chiara Serpente, Maria Sorrentino, Federica Isgrò, Giovanni Turkheimer, Federico Scarpini, Elio Galimberti, Daniela |
author_facet | Arighi, Andrea Arcaro, Marina Fumagalli, Giorgio Giulio Carandini, Tiziana Pietroboni, Anna Margherita Sacchi, Luca Fenoglio, Chiara Serpente, Maria Sorrentino, Federica Isgrò, Giovanni Turkheimer, Federico Scarpini, Elio Galimberti, Daniela |
author_sort | Arighi, Andrea |
collection | PubMed |
description | Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, cerebrospinal fluid (CSF) concentration of AQP4, amyloid-β, total tau and P-tau were determined in 103 CSF samples from patients affected by neurodegenerative dementias (AD and FTD) or psychiatric diseases and 21 controls. Significantly higher levels of AQP4 were found in AD and FTD patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between AQP4 and total tau levels was found. This evidence may pave the way for future studies focused on the role of this channel protein in the clinical assessment of the glymphatic function and degree of neurodegeneration. |
format | Online Article Text |
id | pubmed-9482276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94822762022-09-18 Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation Arighi, Andrea Arcaro, Marina Fumagalli, Giorgio Giulio Carandini, Tiziana Pietroboni, Anna Margherita Sacchi, Luca Fenoglio, Chiara Serpente, Maria Sorrentino, Federica Isgrò, Giovanni Turkheimer, Federico Scarpini, Elio Galimberti, Daniela Alzheimers Res Ther Research Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, cerebrospinal fluid (CSF) concentration of AQP4, amyloid-β, total tau and P-tau were determined in 103 CSF samples from patients affected by neurodegenerative dementias (AD and FTD) or psychiatric diseases and 21 controls. Significantly higher levels of AQP4 were found in AD and FTD patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between AQP4 and total tau levels was found. This evidence may pave the way for future studies focused on the role of this channel protein in the clinical assessment of the glymphatic function and degree of neurodegeneration. BioMed Central 2022-09-17 /pmc/articles/PMC9482276/ /pubmed/36115967 http://dx.doi.org/10.1186/s13195-022-01077-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Arighi, Andrea Arcaro, Marina Fumagalli, Giorgio Giulio Carandini, Tiziana Pietroboni, Anna Margherita Sacchi, Luca Fenoglio, Chiara Serpente, Maria Sorrentino, Federica Isgrò, Giovanni Turkheimer, Federico Scarpini, Elio Galimberti, Daniela Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
title | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
title_full | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
title_fullStr | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
title_full_unstemmed | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
title_short | Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
title_sort | aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482276/ https://www.ncbi.nlm.nih.gov/pubmed/36115967 http://dx.doi.org/10.1186/s13195-022-01077-6 |
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