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Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation

Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer’s di...

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Autores principales: Arighi, Andrea, Arcaro, Marina, Fumagalli, Giorgio Giulio, Carandini, Tiziana, Pietroboni, Anna Margherita, Sacchi, Luca, Fenoglio, Chiara, Serpente, Maria, Sorrentino, Federica, Isgrò, Giovanni, Turkheimer, Federico, Scarpini, Elio, Galimberti, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482276/
https://www.ncbi.nlm.nih.gov/pubmed/36115967
http://dx.doi.org/10.1186/s13195-022-01077-6
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author Arighi, Andrea
Arcaro, Marina
Fumagalli, Giorgio Giulio
Carandini, Tiziana
Pietroboni, Anna Margherita
Sacchi, Luca
Fenoglio, Chiara
Serpente, Maria
Sorrentino, Federica
Isgrò, Giovanni
Turkheimer, Federico
Scarpini, Elio
Galimberti, Daniela
author_facet Arighi, Andrea
Arcaro, Marina
Fumagalli, Giorgio Giulio
Carandini, Tiziana
Pietroboni, Anna Margherita
Sacchi, Luca
Fenoglio, Chiara
Serpente, Maria
Sorrentino, Federica
Isgrò, Giovanni
Turkheimer, Federico
Scarpini, Elio
Galimberti, Daniela
author_sort Arighi, Andrea
collection PubMed
description Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, cerebrospinal fluid (CSF) concentration of AQP4, amyloid-β, total tau and P-tau were determined in 103 CSF samples from patients affected by neurodegenerative dementias (AD and FTD) or psychiatric diseases and 21 controls. Significantly higher levels of AQP4 were found in AD and FTD patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between AQP4 and total tau levels was found. This evidence may pave the way for future studies focused on the role of this channel protein in the clinical assessment of the glymphatic function and degree of neurodegeneration.
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spelling pubmed-94822762022-09-18 Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation Arighi, Andrea Arcaro, Marina Fumagalli, Giorgio Giulio Carandini, Tiziana Pietroboni, Anna Margherita Sacchi, Luca Fenoglio, Chiara Serpente, Maria Sorrentino, Federica Isgrò, Giovanni Turkheimer, Federico Scarpini, Elio Galimberti, Daniela Alzheimers Res Ther Research Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, cerebrospinal fluid (CSF) concentration of AQP4, amyloid-β, total tau and P-tau were determined in 103 CSF samples from patients affected by neurodegenerative dementias (AD and FTD) or psychiatric diseases and 21 controls. Significantly higher levels of AQP4 were found in AD and FTD patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between AQP4 and total tau levels was found. This evidence may pave the way for future studies focused on the role of this channel protein in the clinical assessment of the glymphatic function and degree of neurodegeneration. BioMed Central 2022-09-17 /pmc/articles/PMC9482276/ /pubmed/36115967 http://dx.doi.org/10.1186/s13195-022-01077-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Arighi, Andrea
Arcaro, Marina
Fumagalli, Giorgio Giulio
Carandini, Tiziana
Pietroboni, Anna Margherita
Sacchi, Luca
Fenoglio, Chiara
Serpente, Maria
Sorrentino, Federica
Isgrò, Giovanni
Turkheimer, Federico
Scarpini, Elio
Galimberti, Daniela
Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
title Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
title_full Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
title_fullStr Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
title_full_unstemmed Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
title_short Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
title_sort aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482276/
https://www.ncbi.nlm.nih.gov/pubmed/36115967
http://dx.doi.org/10.1186/s13195-022-01077-6
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