Cargando…

Effects of CRISPR/Cas9-mediated stearoyl-Coenzyme A desaturase 1 knockout on mouse embryo development and lipid synthesis

BACKGROUND: Lipid synthesis is an indispensable process during embryo and growth development. Abnormal lipid synthesis metabolism can cause multiple metabolic diseases including obesity and hyperlipidemia. Stearoyl-Coenzyme A desaturase 1 (SCD1) is responsible for catalyzing the synthesis of monouns...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Huibin, Niu, Huimin, Luo, Jun, Yao, Weiwei, Gao, Wenchang, Wen, Yang, Cheng, Min, Lei, Anmin, Hua, Jinlian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2022
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482360/ https://www.ncbi.nlm.nih.gov/pubmed/36124130 http://dx.doi.org/10.7717/peerj.13945

Ejemplares similares

Effects of overfeeding on the fatty acid profile and stearoyl-CoA desaturase-1 indices in the liver and subcutaneous adipose tissue in cats
por: IWAZAKI, Eiji, et al.
Publicado: (2019)

Efficient knockout of phytoene desaturase gene using CRISPR/Cas9 in melon
por: Hooghvorst, Isidre, et al.
Publicado: (2019)

Knockout of phytoene desaturase gene using CRISPR/Cas9 in highbush blueberry
por: Vaia, Giuseppe, et al.
Publicado: (2022)

Multiplex CRISPR/Cas9-mediated knockout of the phytoene desaturase gene in Coffea canephora
por: Casarin, Tatiane, et al.
Publicado: (2022)

Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
por: Elshorbagy, Amany K., et al.
Publicado: (2011)

Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy
por: Zhou, Youping, et al.
Publicado: (2020)

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice
por: Nuber, Silke, et al.
Publicado: (2020)

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function
por: Isaac, R Stefan, et al.
Publicado: (2016)

Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase
por: Hellemans, Karine H., et al.
Publicado: (2009)

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells
por: Zhang, Jun, et al.
Publicado: (2013)

Sodium Orthovanadate Changes Fatty Acid Composition and Increased Expression of Stearoyl-Coenzyme A Desaturase in THP-1 Macrophages
por: Korbecki, Jan, et al.
Publicado: (2019)

Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase
por: Shi, Xun, et al.
Publicado: (2013)

Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression
por: Li, Weihua, et al.
Publicado: (2018)

Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?
por: Poloni, Soraia, et al.
Publicado: (2015)

The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes
por: Wu, Xiaoyun, et al.
Publicado: (2013)

Stearoyl-CoA Desaturase Is Essential for Porcine Adipocyte Differentiation
por: Liu, Lulu, et al.
Publicado: (2020)

Role of Stearoyl-CoA Desaturase 1 in Cardiovascular Physiology
por: Balatskyi, Volodymyr V., et al.
Publicado: (2023)

Efficient CRISPR/Cas9 Genome Editing of Phytoene desaturase in Cassava
por: Odipio, John, et al.
Publicado: (2017)

Interplay between Thyroid Hormones and Stearoyl-CoA Desaturase 1 in the Regulation of Lipid Metabolism in the Heart
por: Olichwier, Adam, et al.
Publicado: (2020)

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation‐Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl‐Coenzyme A Desaturase As an Enhancer RNA
por: Benhammou, Jihane N., et al.
Publicado: (2019)

The evolutionary history of the stearoyl-CoA desaturase gene family in vertebrates
por: Castro, L Filipe C, et al.
Publicado: (2011)

Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease
por: Astarita, Giuseppe, et al.
Publicado: (2011)

X-ray Structure of a Mammalian Stearoyl-CoA Desaturase
por: Bai, Yonghong, et al.
Publicado: (2015)

Discovery of Tumor-Specific Irreversible Inhibitors of Stearoyl CoA Desaturase
por: Theodoropoulos, Panayotis C., et al.
Publicado: (2016)

Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease
por: O’Neill, Lucas M., et al.
Publicado: (2020)

IRF7-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production
por: Mayuramart, Oraphan, et al.
Publicado: (2022)

A Phase 1 Randomized, Placebo‐Controlled Trial With a Topical Inhibitor of Stearoyl‐Coenzyme A Desaturase 1 Under Occluded and Nonoccluded Conditions
por: Brigandi, Richard A., et al.
Publicado: (2019)

CRISPR/Cas9-Induced Knockout of miR-24 Reduces Cholesterol and Monounsaturated Fatty Acid Content in Primary Goat Mammary Epithelial Cells
por: Huang, Lian, et al.
Publicado: (2022)

RNA-dependent RNA targeting by CRISPR-Cas9
por: Strutt, Steven C, et al.
Publicado: (2018)

CRISPR/Cas9-mediated mutagenesis of phytoene desaturase in diploid and octoploid strawberry
por: Wilson, Fiona M., et al.
Publicado: (2019)

CRISPR/Cas9-mediated precise targeted mutagenesis of phytoene desaturase in celery
por: Liu, Jie-Xia, et al.
Publicado: (2022)

Understanding desaturation/hydroxylation activity of castor stearoyl Δ(9)-Desaturase through rational mutagenesis
por: Tupec, Michal, et al.
Publicado: (2022)

Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer
por: Tracz-Gaszewska, Zuzanna, et al.
Publicado: (2019)

Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer
por: Oatman, Nicole, et al.
Publicado: (2021)

Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes
por: Gan, Ana-Maria, et al.
Publicado: (2022)

Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages
por: Lin, Joseph B., et al.
Publicado: (2023)

Transcriptional Profiles of Diploid Mutant Apis mellifera Embryos after Knockout of csd by CRISPR/Cas9
por: Wang, Xiuxiu, et al.
Publicado: (2021)

Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1
por: Cook, Katherine, et al.
Publicado: (2014)

Gene editing the phytoene desaturase alleles of Cavendish banana using CRISPR/Cas9
por: Naim, Fatima, et al.
Publicado: (2018)

CRISPR-Cas9-induced gene knockout in zebrafish
por: Medishetti, Raghavender, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m2rne2k0hd39mh7grmq1fn7nv9