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Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis

BACKGROUND: Due to chronic respiratory and gastrointestinal problems, growth failure is a common issue in patients with cystic fibrosis (CF). The present study aimed to investigate the prevalence of growth hormone deficiency (GHD) in CF children with stable gastrointestinal and respiratory condition...

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Autores principales: Reisi, Mohsen, Sharif Ahmadian, Niloufar, Hashemipour, Mahin, Mostofizadeh, Neda, Keivanfar, Majid, Hashemi, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482379/
https://www.ncbi.nlm.nih.gov/pubmed/36124019
http://dx.doi.org/10.4103/abr.abr_285_20
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author Reisi, Mohsen
Sharif Ahmadian, Niloufar
Hashemipour, Mahin
Mostofizadeh, Neda
Keivanfar, Majid
Hashemi, Elham
author_facet Reisi, Mohsen
Sharif Ahmadian, Niloufar
Hashemipour, Mahin
Mostofizadeh, Neda
Keivanfar, Majid
Hashemi, Elham
author_sort Reisi, Mohsen
collection PubMed
description BACKGROUND: Due to chronic respiratory and gastrointestinal problems, growth failure is a common issue in patients with cystic fibrosis (CF). The present study aimed to investigate the prevalence of growth hormone deficiency (GHD) in CF children with stable gastrointestinal and respiratory conditions. MATERIALS AND METHODS: In this study, the growth indicators of all 4–16-year-old children referred to two CF clinics were monitored over 3 years. Children without severe gastrointestinal or pulmonary symptoms with weight <3% percentile or whose height increase were two standard deviations below their expected height growth over 6 months were selected for the growth hormone (GH) stimulation test by clonidine and L-dopa test. Some of the children without CF, who were also referred for height growth disorders and matched the CF group, were considered the control group. They underwent the GH stimulation test, and the results were compared. RESULTS: From 150 patients with CF, growth failure was observed in 24 patients with stable gastrointestinal and respiratory conditions; in 10 of them, the GH stimulation test was deficient. The prevalence of GHD was 6.6% in CF patients. In the control group of 30 children without CF, but with growth failure, the GH was deficient in nine cases, implying no significant difference with the case group (P = 0.37). CONCLUSION: In our study, the prevalence of GHD was 6.6% in CF patients, whereas the prevalence GHD in the normal population of childhood is <1%. Therefore, further studies should be designed to investigate the cause of GHD in CF patients.
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spelling pubmed-94823792022-09-18 Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis Reisi, Mohsen Sharif Ahmadian, Niloufar Hashemipour, Mahin Mostofizadeh, Neda Keivanfar, Majid Hashemi, Elham Adv Biomed Res Research Article BACKGROUND: Due to chronic respiratory and gastrointestinal problems, growth failure is a common issue in patients with cystic fibrosis (CF). The present study aimed to investigate the prevalence of growth hormone deficiency (GHD) in CF children with stable gastrointestinal and respiratory conditions. MATERIALS AND METHODS: In this study, the growth indicators of all 4–16-year-old children referred to two CF clinics were monitored over 3 years. Children without severe gastrointestinal or pulmonary symptoms with weight <3% percentile or whose height increase were two standard deviations below their expected height growth over 6 months were selected for the growth hormone (GH) stimulation test by clonidine and L-dopa test. Some of the children without CF, who were also referred for height growth disorders and matched the CF group, were considered the control group. They underwent the GH stimulation test, and the results were compared. RESULTS: From 150 patients with CF, growth failure was observed in 24 patients with stable gastrointestinal and respiratory conditions; in 10 of them, the GH stimulation test was deficient. The prevalence of GHD was 6.6% in CF patients. In the control group of 30 children without CF, but with growth failure, the GH was deficient in nine cases, implying no significant difference with the case group (P = 0.37). CONCLUSION: In our study, the prevalence of GHD was 6.6% in CF patients, whereas the prevalence GHD in the normal population of childhood is <1%. Therefore, further studies should be designed to investigate the cause of GHD in CF patients. Wolters Kluwer - Medknow 2022-07-29 /pmc/articles/PMC9482379/ /pubmed/36124019 http://dx.doi.org/10.4103/abr.abr_285_20 Text en Copyright: © 2022 Advanced Biomedical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Research Article
Reisi, Mohsen
Sharif Ahmadian, Niloufar
Hashemipour, Mahin
Mostofizadeh, Neda
Keivanfar, Majid
Hashemi, Elham
Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis
title Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis
title_full Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis
title_fullStr Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis
title_full_unstemmed Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis
title_short Evaluation of Growth Hormone Deficiency in Children with Cystic Fibrosis
title_sort evaluation of growth hormone deficiency in children with cystic fibrosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482379/
https://www.ncbi.nlm.nih.gov/pubmed/36124019
http://dx.doi.org/10.4103/abr.abr_285_20
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