Cargando…

P2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia

BACKGROUND: Acute myocardial ischemia (AMI) is a common heart disease with increasing morbidity and mortality year by year. Persistent and sterile inflammatory infiltration of myocardial tissue is an important factor triggering of acute myocardial ischemia secondary to acute myocardial infarction, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yanqin, Sun, Xiaoqian, Liu, Xiangning, Li, Junjun, Li, Xuan, Wang, Gang, Liu, Yizhou, Lu, Xiangyu, Cui, Lingwen, Shao, Mingyan, Wang, Yong, Wang, Wei, Li, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482414/ https://www.ncbi.nlm.nih.gov/pubmed/36124207 http://dx.doi.org/10.2147/JIR.S373962

Ejemplares similares

Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice
por: Li, Yanqin, et al.
Publicado: (2022)

Structural mechanism for NEK7-licensed NLRP3 inflammasome activation
por: Sharif, Humayun, et al.
Publicado: (2019)

RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats
por: He, Hao, et al.
Publicado: (2021)

NEK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury
por: Chen, Yuhua, et al.
Publicado: (2019)

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature
por: Liu, Li, et al.
Publicado: (2022)

Corrigendum: NEK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury
por: Chen, Yuhua, et al.
Publicado: (2019)

Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease
por: Cai, HuaiQiu, et al.
Publicado: (2020)

The Critical Role of Potassium Efflux and Nek7 in Pasteurella multocida-Induced NLRP3 Inflammasome Activation
por: Wang, Yu, et al.
Publicado: (2022)

Qishen Granule Improved Cardiac Remodeling via Balancing M1 and M2 Macrophages
por: Lu, Wenji, et al.
Publicado: (2019)

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
por: Shi, Hexin, et al.
Publicado: (2015)

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR
por: Deng, Meng, et al.
Publicado: (2019)

The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC
por: Machtens, Dominik Alexander, et al.
Publicado: (2022)

NEK7-Mediated Activation of NLRP3 Inflammasome Is Coordinated by Potassium Efflux/Syk/JNK Signaling During Staphylococcus aureus Infection
por: Liu, Ruiqing, et al.
Publicado: (2021)

MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation
por: Park, Yeon‐Ji, et al.
Publicado: (2023)

Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus
por: Ma, Zhen-Zhen, et al.
Publicado: (2018)

QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology
por: Li, Meng, et al.
Publicado: (2022)

A Network Pharmacology Approach to Explore the Mechanisms of Qishen Granules in Heart Failure
por: Liu, Junjie, et al.
Publicado: (2019)

Qishen granules regulate intestinal microecology to improve cardiac function in rats with heart failure
por: Gao, Kuo, et al.
Publicado: (2023)

Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism
por: Li, Chun, et al.
Publicado: (2016)

NEK7 inhibition attenuates Aβ(42)-induced cognitive impairment by regulating TLR4/NF-κB and the NLRP3 inflammasome in mice
por: Li, Peng, et al.
Publicado: (2023)

The Protective Effect of Qishen Granule on Heart Failure after Myocardial Infarction through Regulation of Calcium Homeostasis
por: Yang, Xiaomin, et al.
Publicado: (2020)

Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux
por: He, Yuan, et al.
Publicado: (2016)

Wolf–Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation
por: Liu, Caixia, et al.
Publicado: (2021)

Antiapoptosis and Antifibrosis Effects of Qishen Granules on Heart Failure Rats via Hippo Pathway
por: Zhang, Jian, et al.
Publicado: (2019)

Qishen granules exerts cardioprotective effects on rats with heart failure via regulating fatty acid and glucose metabolism
por: Gao, Kuo, et al.
Publicado: (2020)

Qishen Yiqi Drop Pill improves cardiac function after myocardial ischemia
por: JianXin, Chen, et al.
Publicado: (2016)

Safety and efficacy of Qishen granules in patients with chronic heart failure: study protocol for a randomized controlled trial
por: Wang, Jinping, et al.
Publicado: (2017)

Corrigendum to “Antiapoptosis and Antifibrosis Effects of Qishen Granules on Heart Failure Rats via Hippo Pathway”
por: Zhang, Jian, et al.
Publicado: (2020)

NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling
por: Chen, Xueliang, et al.
Publicado: (2019)

Efficacy and safety of Qishen granules for chronic heart failure: A protocol for systematic review and meta-analysis
por: Liu, Junjie, et al.
Publicado: (2020)

Decomposing the Mechanism of Qishen Granules in the Treatment of Heart Failure by a Quantitative Pathway Analysis Method
por: Ren, Weiquan, et al.
Publicado: (2018)

Qishen Granule Protects against Doxorubicin-Induced Cardiotoxicity by Coordinating MDM2-p53-Mediated Mitophagy and Mitochondrial Biogenesis
por: Li, Weili, et al.
Publicado: (2022)

An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7
por: Caseley, Emily A., et al.
Publicado: (2021)

Probing the effect of NEK7 and cofactor interactions on dynamics of NLRP3 monomer using molecular simulation
por: El‐Sayed, Sherihan, et al.
Publicado: (2022)

Kinase Inhibitor Profile for Human Nek1, Nek6, and Nek7 and Analysis of the Structural Basis for Inhibitor Specificity
por: Moraes, Eduardo Cruz, et al.
Publicado: (2015)

The effects of qishen granules for patients with chronic heart failure: A multicenter randomized double-blind placebo-controlled trial
por: Du, Kangjia, et al.
Publicado: (2022)

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
por: Haq, Tamanna, et al.
Publicado: (2015)

Reactive oxygen species induced by uric acid promote NRK-52E cell apoptosis through the NEK7-NLRP3 signaling pathway
por: Li, Dongdong, et al.
Publicado: (2021)

NEK7 Coordinates Rapid Neuroinflammation After Subarachnoid Hemorrhage in Mice
por: Li, Gen, et al.
Publicado: (2020)

Physiological and Pathological Roles of Mammalian NEK7
por: Sun, Zhenzhen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_45l39vg3av7mgq1ioffr7dk55l