A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer’s disease mouse model

Tumor necrosis factor-α (TNF-α) is a pleiotropic, proinflammatory cytokine related to different neurodegenerative diseases, including Alzheimer’s disease (AD). Although the linkage between increased TNF-α levels and AD is widely recognized, TNF-α–neutralizing therapies have failed to treat AD. Previ...

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Detalles Bibliográficos
Autores principales: Ortí-Casañ, Natalia, Zuhorn, Inge S., Naudé, Petrus J. W., De Deyn, Peter P., van Schaik, Pauline E. M., Wajant, Harald, Eisel, Ulrich L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482428/
https://www.ncbi.nlm.nih.gov/pubmed/36037389
http://dx.doi.org/10.1073/pnas.2201137119

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