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PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma

Glioblastoma is a highly aggressive brain tumor for which there is no cure. The metabolic enzyme 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4) is essential for glioblastoma stem-like cell (GSC) survival but its mode of action is unclear. Understanding the role of PFKFB4 in tumor cel...

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Detalles Bibliográficos
Autores principales:	Phillips, Emma, Balss, Jörg, Bethke, Frederic, Pusch, Stefan, Christen, Stefan, Hielscher, Thomas, Schnölzer, Martina, Fletcher, Michael N. C., Habel, Antje, Tessmer, Claudia, Brenner, Lisa-Marie, Göttmann, Mona, Capper, David, Herold-Mende, Christel, von Deimling, Andreas, Fendt, Sarah-Maria, Goidts, Violaine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482633/ https://www.ncbi.nlm.nih.gov/pubmed/36115843 http://dx.doi.org/10.1038/s41389-022-00433-3

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