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Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation

Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide loading complex plays a critical role in antigen presentation and immune recognition. Mechanistic insight has been hampered by the lack of detailed structural information concerning tapasin–MHC-I. We present he...

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Detalles Bibliográficos
Autores principales:	Jiang, Jiansheng, Taylor, Daniel K., Kim, Ellen J., Boyd, Lisa F., Ahmad, Javeed, Mage, Michael G., Truong, Hau V., Woodward, Claire H., Sgourakis, Nikolaos G., Cresswell, Peter, Margulies, David H., Natarajan, Kannan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482634/ https://www.ncbi.nlm.nih.gov/pubmed/36115831 http://dx.doi.org/10.1038/s41467-022-33153-8

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