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Protective effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity in rats
OBJECTIVE: Sodium nitrite (NaNO(2)) is used as a color stabilizer and antimicrobial agent in preservation of cured meat and fish. However, extensive use of this agent in the meat industries increased worries about its detrimental effects on human health. Zataria multiflora (Z. multiflora) is a well-...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Mashhad University of Medical Sciences
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482715/ https://www.ncbi.nlm.nih.gov/pubmed/36186930 http://dx.doi.org/10.22038/AJP.2021.18781 |
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author | Ahmadi, Fatemeh Louei Monfared, Ali Shakarami, Neamatollah |
author_facet | Ahmadi, Fatemeh Louei Monfared, Ali Shakarami, Neamatollah |
author_sort | Ahmadi, Fatemeh |
collection | PubMed |
description | OBJECTIVE: Sodium nitrite (NaNO(2)) is used as a color stabilizer and antimicrobial agent in preservation of cured meat and fish. However, extensive use of this agent in the meat industries increased worries about its detrimental effects on human health. Zataria multiflora (Z. multiflora) is a well-known plant with therapeutic properties in the traditional medicine. Therefore, the present study was conducted to investigate the protective effect of this plant against sodium nitrite-induced hepatotoxicity. MATERIALS AND METHODS: Thirty-two male Wistar rats were divided into 4 groups: Control (without any treatment), nitrite (350 mg/kg by gavage for 60 days), NaNO(2) plus Z. multiflora (rats treated with NaNO(2) 350 mg/kg gavage for 60 days and simultaneously received Z. multiflora extract at 200 mg/kg, ip) and Z. multiflora group (rats treated with Z. multiflora extract at 200 mg/kg, ip). At the end of the study, rats were euthanized and liver tissue samples were taken and studied under microscopy. Also, serum levels of liver function enzymes and antioxidant defense systems were measured. The results were analyzed using SPSS software and a p<0.0.5 was considered significant. RESULTS: Results showed that NaNO(2 )induces liver injuries and altered hepatic histo-architecture. Also, NaNO(2 )significantly altered the biochemical profiles and antioxidant defense parameters of the liver. However, treatment with Z. multiflora improved tissue integrity as well as antioxidant defense status and biochemical conditions of the liver. CONCLUSION: Administration of Z. multiflora extract has beneficial effects on the NaNO(2)-induced histological and functional toxicity in the liver. |
format | Online Article Text |
id | pubmed-9482715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Mashhad University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-94827152022-09-29 Protective effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity in rats Ahmadi, Fatemeh Louei Monfared, Ali Shakarami, Neamatollah Avicenna J Phytomed Short Communication OBJECTIVE: Sodium nitrite (NaNO(2)) is used as a color stabilizer and antimicrobial agent in preservation of cured meat and fish. However, extensive use of this agent in the meat industries increased worries about its detrimental effects on human health. Zataria multiflora (Z. multiflora) is a well-known plant with therapeutic properties in the traditional medicine. Therefore, the present study was conducted to investigate the protective effect of this plant against sodium nitrite-induced hepatotoxicity. MATERIALS AND METHODS: Thirty-two male Wistar rats were divided into 4 groups: Control (without any treatment), nitrite (350 mg/kg by gavage for 60 days), NaNO(2) plus Z. multiflora (rats treated with NaNO(2) 350 mg/kg gavage for 60 days and simultaneously received Z. multiflora extract at 200 mg/kg, ip) and Z. multiflora group (rats treated with Z. multiflora extract at 200 mg/kg, ip). At the end of the study, rats were euthanized and liver tissue samples were taken and studied under microscopy. Also, serum levels of liver function enzymes and antioxidant defense systems were measured. The results were analyzed using SPSS software and a p<0.0.5 was considered significant. RESULTS: Results showed that NaNO(2 )induces liver injuries and altered hepatic histo-architecture. Also, NaNO(2 )significantly altered the biochemical profiles and antioxidant defense parameters of the liver. However, treatment with Z. multiflora improved tissue integrity as well as antioxidant defense status and biochemical conditions of the liver. CONCLUSION: Administration of Z. multiflora extract has beneficial effects on the NaNO(2)-induced histological and functional toxicity in the liver. Mashhad University of Medical Sciences 2022 /pmc/articles/PMC9482715/ /pubmed/36186930 http://dx.doi.org/10.22038/AJP.2021.18781 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Ahmadi, Fatemeh Louei Monfared, Ali Shakarami, Neamatollah Protective effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity in rats |
title | Protective effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity in rats |
title_full | Protective effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity in rats |
title_fullStr | Protective effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity in rats |
title_full_unstemmed | Protective effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity in rats |
title_short | Protective effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity in rats |
title_sort | protective effect of zataria multiflora boiss against sodium nitrite-induced hepatotoxicity in rats |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482715/ https://www.ncbi.nlm.nih.gov/pubmed/36186930 http://dx.doi.org/10.22038/AJP.2021.18781 |
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